|
|
|
|
| LEADER |
01000caa a22002652 4500 |
| 001 |
NLM213973855 |
| 003 |
DE-627 |
| 005 |
20240321232410.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2012 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/la203846w
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n1338.xml
|
| 035 |
|
|
|a (DE-627)NLM213973855
|
| 035 |
|
|
|a (NLM)22182057
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Saha, Sharmistha
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Electrospun fibrous scaffolds promote breast cancer cell alignment and epithelial-mesenchymal transition
|
| 264 |
|
1 |
|c 2012
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 23.05.2012
|
| 500 |
|
|
|a Date Revised 21.03.2024
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2011 American Chemical Society
|
| 520 |
|
|
|a In this work we created electrospun fibrous scaffolds with random and aligned fiber orientations in order to mimic the three-dimensional structure of the natural extracellular matrix (ECM). The rigidity and topography of the ECM environment have been reported to alter cancer cell behavior. However, the complexity of the in vivo system makes it difficult to isolate and study such extracellular topographical cues that trigger cancer cells' response. Breast cancer cells were cultured on these fibrous scaffolds for 3-5 days. The cells showed elongated spindle-like morphology in the aligned fibers, whereas they maintained a mostly flat stellar shape in the random fibers. Gene expression profiling of these cells post seeding showed up-regulation of transforming growth factor β-1 (TGFβ-1) along with other mesenchymal biomarkers, suggesting that these cells undergo epithelial-mesenchymal transitions in response to the polymer scaffold. The results of this study indicate that the topographical cue may play a significant role in tumor progression
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
|
| 650 |
|
7 |
|a Polyesters
|2 NLM
|
| 650 |
|
7 |
|a Transforming Growth Factor beta
|2 NLM
|
| 650 |
|
7 |
|a polycaprolactone
|2 NLM
|
| 650 |
|
7 |
|a 24980-41-4
|2 NLM
|
| 700 |
1 |
|
|a Duan, Xinrui
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wu, Laying
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Lo, Pang-Kuo
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Hexin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Qian
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 4 vom: 31. Jan., Seite 2028-34
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:28
|g year:2012
|g number:4
|g day:31
|g month:01
|g pages:2028-34
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la203846w
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 28
|j 2012
|e 4
|b 31
|c 01
|h 2028-34
|