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231224s2012 xx |||||o 00| ||eng c |
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7 |
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|a 10.1021/la204388h
|2 doi
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|a pubmed24n0713.xml
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|a eng
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| 100 |
1 |
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|a Dal Bó, Alexandre G
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Self-assembly of amphiphilic glycoconjugates into lectin-adhesive nanoparticles
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| 264 |
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 01.05.2012
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|a Date Revised 17.01.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a This work describes the synthesis and self-assembly of carbohydrate-clicked rod-coil amphiphilic systems. Copper-catalyzed Huisgen cycloaddition was efficiently employed to functionalize the hydrophilic extremity of PEG-b-tetra(p-phenylene) conjugates by lactose and N-acetyl-glucosamine ligands. The resulting amphiphilic systems spontaneously self-assembled into nanoparticles when dissolved in aqueous media, as evidenced by dynamic light scattering (DLS), transmission electron microscopy (TEM), and small-angle X-ray scattering (SAXS). The formation of highly monodisperse micelles having a mean diameter of 10 nm was observed for systems containing a PEG 900 core, and a decrease in the hydrophilic moiety (PEG 600) led to the formation of vesicles with a broader size distribution. The presence of carbohydrate residues on the surfaces of the micelles and their ability to establish specific interactions with wheat germ agglutinin (WGA) and peanut agglutinin (PNA) were further highlighted by light-scattering measurements, thus confirming the attractive applications of such sugar micelles in biosensor devices
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Adhesives
|2 NLM
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|a Glycoconjugates
|2 NLM
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| 650 |
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|a Lectins
|2 NLM
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| 700 |
1 |
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|a Soldi, Valdir
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Giacomelli, Fernando C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Travelet, Christophe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jean, Bruno
|e verfasserin
|4 aut
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1 |
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|a Pignot-Paintrand, Isabelle
|e verfasserin
|4 aut
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|a Borsali, Redouane
|e verfasserin
|4 aut
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| 700 |
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|a Fort, Sébastien
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 2 vom: 17. Jan., Seite 1418-26
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:28
|g year:2012
|g number:2
|g day:17
|g month:01
|g pages:1418-26
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