Electrochemical modeling of the silica nanoparticle-biomembrane interaction
© 2011 American Chemical Society
| Veröffentlicht in: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 28(2012), 2 vom: 17. Jan., Seite 1246-55 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Zugriff auf das übergeordnete Werk: | Langmuir : the ACS journal of surfaces and colloids |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Membranes, Artificial Silicon Dioxide 7631-86-9 |
| Zusammenfassung: | © 2011 American Chemical Society The interaction of amorphous colloidal silica (SiO(2)) nanoparticles of well-defined sizes with a dioleoyl phosphatidylcholine (DOPC) monolayer on a mercury (Hg) film electrode has been investigated. It was shown using electrochemical methods and microcalorimetry that particles interact with the monolayer, and the electrochemical data shows that the extent of interaction is inversely proportional to the particle size. Scanning electron microscopy (SEM) images of the electrode-supported monolayers following exposure to the particles shows that the nanoparticles bind to the DOPC monolayer irrespective of their size, forming a particle monolayer on the DOPC surface. A one-parameter model was developed to describe the electrochemical results where the fitted parameter is an interfacial layer thickness (3.2 nm). The model is based on the adsorptive interactions operating within this interfacial layer that are independent of the solution pH and solution ionic strength. The evidence implies that the most significant forces determining the interactions are van der Waals in character |
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| Beschreibung: | Date Completed 01.05.2012 Date Revised 17.01.2012 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1520-5827 |
| DOI: | 10.1021/la203568n |