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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la203338v
|2 doi
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|a eng
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1 |
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|a Sharma, Vishal
|e verfasserin
|4 aut
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| 245 |
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|a Formation of polymeric toroidal-spiral particles
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a Date Completed 25.04.2012
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|a Date Revised 10.01.2012
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Compared to spherical matrices, particles with well-defined internal structure provide large surface to volume ratio and predictable release kinetics for the encapsulated payloads. We describe self-assembly of polymeric particles, whereby competitive kinetics of viscous sedimentation, diffusion, and cross-linking yield a controllable toroidal-spiral (T-S) structure. Precursor polymeric droplets are splashed through the surface of a less dense, miscible solution, after which viscous forces entrain the surrounding bulk solution into the sedimenting polymer drop to form T-S channels. The intricate structure forms because low interfacial tension between the two miscible solutions is dominated by viscous forces. The biocompatible polymer, poly(ethylene glycol) diacrylate (PEG-DA), is used to demonstrate the solidification of the T-S shapes at various configurational stages by UV-triggered cross-linking. The dimensions of the channels are controlled by Weber number during impact on the surface, and Reynolds number and viscosity ratio during subsequent sedimentation. We anticipate applications of the T-S particle in drug delivery, wherein diffusion through these T-S channels and the polymer matrix would offer parallel release pathways for molecules of different sizes. Polyphosphate, as a model macromolecule, is entrained in T-S particles during their formation. The in vitro release kinetics of polyphosphate from the T-S particles with various channel length and width is reported. In addition, self-assembly of T-S particles occurs in a single step under benign conditions for delicate macromolecules, and appears conducive to scaleup
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|a Journal Article
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Biocompatible Materials
|2 NLM
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|a Polymers
|2 NLM
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1 |
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|a Szymusiak, Magdalena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shen, Hao
|e verfasserin
|4 aut
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1 |
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|a Nitsche, Ludwig C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Ying
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 28(2012), 1 vom: 10. Jan., Seite 729-35
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:28
|g year:2012
|g number:1
|g day:10
|g month:01
|g pages:729-35
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|u http://dx.doi.org/10.1021/la203338v
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