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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la203413b
|2 doi
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|a pubmed24n0710.xml
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|a eng
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|a Hennig, Martin
|e verfasserin
|4 aut
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|a DNA concentration modulation on supported lipid bilayers switched by surface acoustic waves
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 24.04.2012
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|a Date Revised 14.12.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a Spatially addressable arrays of molecules embedded in or anchored to supported lipid bilayers are important for on-chip screening and binding assays; however, methods to sort or accumulate components in a fluid membrane on demand are still limited. Here we apply in-plane surface acoustic shear waves (SAWs) to laterally accumulate double-stranded DNA segments electrostatically bound to a cationic supported lipid bilayer. The fluorescently labeled DNA segments are found to segregate into stripe patterns with a spatial frequency corresponding to the periodicity of the standing SAW wave (~10 μm). The DNA molecules are accumulated 10-fold in the regions of SAW antinodes. The superposition of two orthogonal sets of SAW sources creates checkerboard like arrays of DNA demonstrating the potential to generate arrayed fields dynamically. The pattern relaxation time of 0.58 s, which is independent of the segment length, indicates a sorting and relaxation mechanism dominated by lipid diffusion rather than DNA self-diffusion
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Bilayers
|2 NLM
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|a Xanthenes
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|a Texas red
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|a 82354-19-6
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|a DNA
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|a 9007-49-2
|2 NLM
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|a Wolff, Manuel
|e verfasserin
|4 aut
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|a Neumann, Jürgen
|e verfasserin
|4 aut
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|a Wixforth, Achim
|e verfasserin
|4 aut
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|a Schneider, Matthias F
|e verfasserin
|4 aut
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|a Rädler, Joachim O
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 24 vom: 20. Dez., Seite 14721-5
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:27
|g year:2011
|g number:24
|g day:20
|g month:12
|g pages:14721-5
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|u http://dx.doi.org/10.1021/la203413b
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