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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la2030318
|2 doi
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|a pubmed24n0708.xml
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|a (NLM)22017569
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|a DE-627
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|e rakwb
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|a eng
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|a Choi, Jiyeon
|e verfasserin
|4 aut
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|a Improvement of interfacial adhesion of biodegradable polymers coated on metal surface by nanocoupling
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 27.03.2012
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a A method of securing the adhesion of biodegradable polymer coating was investigated for drug-eluting metal stents, using surface-initiated ring-opening polymerization (SI-ROP) of L-lactide. Introduction of oligolactide on the stainless steel (SS) surface was successful and the thickness of the oligolactide grafts remained on the nanometer scale, as determined by ellipsometry. The presence of an oligolactide graft was also identified using attenuated total reflection-Fourier transform infrared (ATR-FTIR) and electron spectroscopy for chemical analysis (ESCA). On top of the grafts, poly(D,L-lactide-co-glycolide) (PLGA) coating was carried out on different substrates such as SS control, plasma-treated SS, and lactide-grafted (referred to as a nanocoupled) SS using electrospraying. When the adhesion forces were measured with a scratch tester, the nanocoupled SS showed the strongest interfacial adhesion between polymer coating layer and metal substrate. The outcome of the peel-off test was also consistent with the result of the scratch test. When degradation behavior of the polymer coating in vitro was examined for up to 4 weeks in a continuous fluid flow, the SEM images demonstrated that polymer degradation was obvious due to hydration and swelling of the polymer matrix. Although the matrix completely disappeared after 4 weeks for SS control and plasma-treated substrates, the nanocoupled SS was persistent with some polymer matrix. In addition, the release profiles of SRL-loaded PLGA coating appeared slightly different between control and nanocoupled groups. This work suggested that the concept of nanocoupling remarkably improved the interfacial adhesion stability between metal surface and polymer layer and controlled drug release, and showed the feasibility of drug-eluting stents
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Stainless Steel
|2 NLM
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|a 12597-68-1
|2 NLM
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|a Polylactic Acid-Polyglycolic Acid Copolymer
|2 NLM
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|a 1SIA8062RS
|2 NLM
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|a Polyglycolic Acid
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|2 NLM
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|a Lactic Acid
|2 NLM
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|a 33X04XA5AT
|2 NLM
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1 |
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|a Cho, Seong Bae
|e verfasserin
|4 aut
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|a Lee, Bong Soo
|e verfasserin
|4 aut
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|a Joung, Yoon Ki
|e verfasserin
|4 aut
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|a Park, Kwideok
|e verfasserin
|4 aut
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|a Han, Dong Keun
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 23 vom: 06. Dez., Seite 14232-9
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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|g volume:27
|g year:2011
|g number:23
|g day:06
|g month:12
|g pages:14232-9
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|u http://dx.doi.org/10.1021/la2030318
|3 Volltext
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