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231224s2011 xx ||||| 00| ||chi c |
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|a pubmed25n0707.xml
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|a (DE-627)NLM212291289
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|a (NLM)22005561
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a chi
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| 100 |
1 |
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|a Nie, Cheng
|e verfasserin
|4 aut
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|a A clinical study on organ protective effect of early high-volume hemofiltration (HVHF) in patients with multiple organ dysfunction syndrome (MODS) complicated by acute kidney injury (AKI)
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 14.06.2012
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|a Date Revised 18.10.2011
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To investigate the organ protective effect of early continuous HVHF in patients with MODS complicated by AKI
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|a METHODS: 117 patients requested HVHF in ICU due to MODS/AKI were enrolled from June 2006 to June 2011 for clinical data collection. The patients were categorized, by RIFLE scale (R-risk of renal dysfunction, I-injury to the kidney, F-failure of kidney, L-loss of kidney function, E-end stage kidney disease), into three groups: RIFLE-R (n = 15), RIFLE-I (n = 23) and RIFLE-F (n = 79). The values of their serum creatinine (SCr), oxygenation index (PaO(2) /FiO(2) ), extravascular lung water index (EVLWI), blood lactic acid (Lac), prothrombin time (PT), aspartate aminotransferase (AST), acute physiology and chronic health evaluation II (APACHE II) score were recorded, at the beginning of, and within 72 hours after HVHF. The 90-day survival rate in each group was calculated
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|a RESULTS: No significant difference was found between RIFLE-R and RIFLE-I group, within 72 hours after HVHF, in SCr, PaO(2) /FiO(2) , EVLWI, Lac, PT, AST, or APACHE II score. The mean values of SCr, EVLWI, Lac, PT, AST, APACHE II score, within 72 hours after HVHF in the RIFLE-F group were significantly higher in comparison with RIFLE-R, and RIFLE-I group [SCr (μmol/L): 260.50±35.51 vs. 83.61±21.07, 89.71±23.81 ; EVLWI (ml/kg): 12.18±2.11 vs. 10.94±1.50,10.76±1.92; Lac (mmol/L): 2.40±0.56 vs. 1.58±0.27, 1.68±0.35; PT (sec): 14.14±1.50 vs. 12.67±1.18, 12.51±0.94; AST (U/L): 96.19±18. 84 vs. 47.91±12.85, 56.39±13.44; APACHE II score: 20.17±2.61 vs. 17.79±2.65, 18.53±2.87, P< 0.05 or P< 0.01]; However, the PaO(2) /FiO(2) (mm Hg, 1 mm Hg = 0.133 kPa) value in RIFLE-F group was found significantly lower compared to RIFLE-R and RIFLE-I group (202.80±19.07 vs. 245.24±21.18, 250.63±25.56, P< 0.01). No statistical significant difference was found in the 90-day survival rate among RIFLE-R, RIFLE-I and RIFLE-F group (66.67%, 65.22%, 63.29%, respectively, P> 0.05)
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|a CONCLUSION: Early HVHF has protective effect against organs injury in patients with MODS and AKI
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|a English Abstract
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| 650 |
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 700 |
1 |
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|a Qian, Ke-jian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Lian-qun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Fen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Zhen-guo
|e verfasserin
|4 aut
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| 700 |
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|a Zhu, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhan, Yi-an
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 23(2011), 10 vom: 15. Okt., Seite 605-7
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
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|g volume:23
|g year:2011
|g number:10
|g day:15
|g month:10
|g pages:605-7
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 23
|j 2011
|e 10
|b 15
|c 10
|h 605-7
|