Pulmonary platelet endothelial cell adhesion molecule-1 (PECAM-1) in rabbits after acute paraquat (PQ) poisoning
OBJECTIVE: To examine the changes in PECAM-1 expression and its correlation to the level of pulmonary tissue injury in the lungs from rabbits exposed to acute PQ poisoning
| Veröffentlicht in: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 23(2011), 10 vom: 15. Okt., Seite 585-7 |
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| 1. Verfasser: | |
| Weitere Verfasser: | , , |
| Format: | Aufsatz |
| Sprache: | Chinese |
| Veröffentlicht: |
2011
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| Zugriff auf das übergeordnete Werk: | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Platelet Endothelial Cell Adhesion Molecule-1 Paraquat PLG39H7695 |
| Zusammenfassung: | OBJECTIVE: To examine the changes in PECAM-1 expression and its correlation to the level of pulmonary tissue injury in the lungs from rabbits exposed to acute PQ poisoning METHODS: Three groups of New Zealand rabbits (12 each, randomly assigned) were treated with PQ at 8, 16 and 32 mg/kg respectively through gavage. The animals were sacrificed 7 days after the poisoning and the upper lobe of their lungs collected for semi-quantitative microscopic evaluation of tissue injury, pulmonary fibrosis and the expression of PECAM-1 after hematoxylin-eosin (HE), Masson, and immuno-histological staining. The correlation analysis was used for the relationship between the expression of PECAM-1 and lung injury score or fibrosis of lung RESULTS: The evaluation scores (demonstrated as mean+ standard deviation) in the three treatment groups were found to be (a) 8.33±1.03, 9.83±1.17 and 11.50±1.38 for lung tissue injury, (b) (31.09±2.05)%, (34.37±1.62)% and (36.54±0.44)% for pulmonary fibrosis, and (c) (20.31± 0.70)%, (19.34±0.68)% and (18.37±0.46)% for PECAM-1 expression. Statistically significant difference (P< 0.05) was found between the results from different dose groups for all the indexes examined. Pearson correlation analysis showed that expression of PECAM-1 was negatively correlated to lung injury score ( r = - 0.732, P = 0.001) and fibrosis degree of lung ( r = - 0. 779, P< 0.001) CONCLUSION: (1) The expressions of PECAM-1 in the lungs of PQ treated animals decrease to increased dose of PQ poisoning, (2) such decrease is correlated to the degree of pulmonary tissue injury and fibrosis of lung. It is possible that PECAM-1 expression inhibition be an important factor in the development of lung injury after acute PQ poisoning |
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| Beschreibung: | Date Completed 14.06.2012 Date Revised 16.11.2017 published: Print Citation Status MEDLINE |
| ISSN: | 1003-0603 |