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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1111/j.1469-8137.2011.03926.x
|2 doi
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|a eng
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|a Waterworth, Wanda M
|e verfasserin
|4 aut
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|a Repairing breaks in the plant genome
|b the importance of keeping it together
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|a ƒa Online-Ressource
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|a Date Completed 12.03.2012
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 The Authors. New Phytologist © 2011 New Phytologist Trust.
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|a DNA damage threatens the integrity of the genome and has potentially lethal consequences for the organism. Plant DNA is under continuous assault from endogenous and environmental factors and effective detection and repair of DNA damage are essential to ensure the stability of the genome. One of the most cytotoxic forms of DNA damage are DNA double-strand breaks (DSBs) which fragment chromosomes. Failure to repair DSBs results in loss of large amounts of genetic information which, following cell division, severely compromises daughter cells that receive fragmented chromosomes. This review will survey recent advances in our understanding of plant responses to chromosomal breaks, including the sources of DNA damage, the detection and signalling of DSBs, mechanisms of DSB repair, the role of chromatin structure in repair, DNA damage signalling and the link between plant recombination pathways and transgene integration. These mechanisms are of critical importance for maintenance of plant genome stability and integrity under stress conditions and provide potential targets for the improvement of crop plants both for stress resistance and for increased precision in the generation of genetically improved varieties
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Review
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|a Mutagens
|2 NLM
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|a Drury, Georgina E
|e verfasserin
|4 aut
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|a Bray, Clifford M
|e verfasserin
|4 aut
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|a West, Christopher E
|e verfasserin
|4 aut
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|i Enthalten in
|t The New phytologist
|d 1979
|g 192(2011), 4 vom: 04. Dez., Seite 805-822
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|x 1469-8137
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|g volume:192
|g year:2011
|g number:4
|g day:04
|g month:12
|g pages:805-822
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|u http://dx.doi.org/10.1111/j.1469-8137.2011.03926.x
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