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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la202970g
|2 doi
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|a pubmed24n0706.xml
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Méndez, Manuel A
|e verfasserin
|4 aut
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|a Melittin adsorption and lipid monolayer disruption at liquid-liquid interfaces
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 06.03.2012
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|a Date Revised 08.11.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Melittin, a membrane-active peptide with antimicrobial activity, was investigated at the interface formed between two immiscible electrolyte solutions (ITIES) supported on a metallic electrode. Ion-transfer voltammetry showed well-defined semi-reversible transfer peaks along with adsorptive peaks. The reversible adsorption of melittin at the liquid-liquid interface is qualitatively discussed from voltammetric data and experimentally confirmed by real-time image analysis of video snapshots. It is also demonstrated that polarization of the water/1,2-DCE interface results in drastic drop shape variations caused by large variations of the interfacial tension. The experimental data also confirmed that maximum adsorption occurs near the ion transfer potential. Finally, the interaction of melittin with a monolayer of L-α-dipalmitoyl phosphatidylcholine (DPPC) was also investigated showing that melittin destabilizes the lipidic monolayer facilitating its desorption. The non-covalent complex formation between melittin and DPPC was confirmed by mass spectrometry
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Melitten
|2 NLM
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|a 20449-79-0
|2 NLM
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|a 1,2-Dipalmitoylphosphatidylcholine
|2 NLM
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| 650 |
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|a 2644-64-6
|2 NLM
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| 700 |
1 |
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|a Nazemi, Zahra
|e verfasserin
|4 aut
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1 |
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|a Uyanik, Ibrahim
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Yu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Girault, Hubert H
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 27(2011), 22 vom: 15. Nov., Seite 13918-24
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:27
|g year:2011
|g number:22
|g day:15
|g month:11
|g pages:13918-24
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|u http://dx.doi.org/10.1021/la202970g
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