A tissue-mimicking ultrasound test object using droplet vaporization to create point targets

Ultrasound test objects containing reference point targets could be useful for evaluating ultrasound systems and phase aberration correction methods. Polyacrylamide gels containing albumin-stabilized droplets (3.6 μm mean diameter) of dodecafluoropentane (DDFP) are being developed for this purpose....

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Veröffentlicht in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control. - 1986. - 58(2011), 9 vom: 15. Sept., Seite 2013-25
1. Verfasser: Carneal, Catherine M (VerfasserIn)
Weitere Verfasser: Kripfgans, Oliver D, Krücker, Jochen, Carson, Paul L, Fowlkes, J Brian
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:IEEE transactions on ultrasonics, ferroelectrics, and frequency control
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Acrylic Resins Albumins Fluorocarbons polyacrylamide gels perfluoropentane 678-26-2
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520 |a Ultrasound test objects containing reference point targets could be useful for evaluating ultrasound systems and phase aberration correction methods. Polyacrylamide gels containing albumin-stabilized droplets (3.6 μm mean diameter) of dodecafluoropentane (DDFP) are being developed for this purpose. Perturbation by ultrasound causes spontaneous vaporization of the superheated droplets to form gas bubbles, a process termed acoustic droplet vaporization (ADV). The resulting bubbles (20 to 160 μmm diameter) are small compared with acoustic wavelengths in diagnostic ultrasound and are theoretically suitable for use as point targets (phase errors < 20° for typical f-numbers). Bubbles distributed throughout the material are convenient for determining the point spread function in an imaging plane or volume. Cooling the gel causes condensation of the DDFP droplets, which may be useful for storage. Studying ADV in such viscoelastic media could provide insight into potential bioeffects from rapid bubble formation 
650 4 |a Journal Article 
650 4 |a Research Support, N.I.H., Extramural 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
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650 7 |a Albumins  |2 NLM 
650 7 |a Fluorocarbons  |2 NLM 
650 7 |a polyacrylamide gels  |2 NLM 
650 7 |a perfluoropentane  |2 NLM 
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700 1 |a Kripfgans, Oliver D  |e verfasserin  |4 aut 
700 1 |a Krücker, Jochen  |e verfasserin  |4 aut 
700 1 |a Carson, Paul L  |e verfasserin  |4 aut 
700 1 |a Fowlkes, J Brian  |e verfasserin  |4 aut 
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