Biocidal activity of plasma modified electrospun polysulfone mats functionalized with polyethyleneimine-capped silver nanoparticles

The incorporation of silver nanoparticles (AgNPs) into polymeric nanofibers has attracted a great deal of attention due to the strong antimicrobial activity that the resulting fibers exhibit. However, bactericidal efficacy of AgNP-coated electrospun fibrous mats has not yet been demonstrated. In thi...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 27(2011), 21 vom: 01. Nov., Seite 13159-64
1. Verfasser: Schiffman, Jessica D (VerfasserIn)
Weitere Verfasser: Wang, Yue, Giannelis, Emmanuel P, Elimelech, Menachem
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Anti-Bacterial Agents Plasma Gases Polymers Sulfones polysulfone P 1700 25135-51-7 Silver mehr... 3M4G523W1G Polyethyleneimine 9002-98-6
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520 |a The incorporation of silver nanoparticles (AgNPs) into polymeric nanofibers has attracted a great deal of attention due to the strong antimicrobial activity that the resulting fibers exhibit. However, bactericidal efficacy of AgNP-coated electrospun fibrous mats has not yet been demonstrated. In this study, polysulfone (PSf) fibers were electrospun and surface-modified using an oxygen plasma treatment, which allowed for facile irreversible deposition of cationically charged polyethyleneimine (PEI)-AgNPs via electrostatic interactions. The PSf-AgNP mats were characterized for relative silver concentration as a function of plasma treatment time using ICP-MS and changes in contact angle. Plasma treatment of 60 s was the shortest time required for maximum loss of bacteria (Escherichia coli) viability. Time-dependent bacterial cytotoxicity studies indicate that the optimized PSf-AgNP mats exhibit a high level of inactivation against both gram negative bacteria, Escherichia coli, and gram positive bacteria, Bacillus anthracis and Staphylococcus aureus 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 4 |a Research Support, U.S. Gov't, Non-P.H.S. 
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650 7 |a Polyethyleneimine  |2 NLM 
650 7 |a 9002-98-6  |2 NLM 
700 1 |a Wang, Yue  |e verfasserin  |4 aut 
700 1 |a Giannelis, Emmanuel P  |e verfasserin  |4 aut 
700 1 |a Elimelech, Menachem  |e verfasserin  |4 aut 
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