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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2011.08.005
|2 doi
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|a pubmed24n0705.xml
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|a (DE-627)NLM211500941
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|a (NLM)21920821
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Dolff, Sebastian
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Disturbed Th1, Th2, Th17 and T(reg) balance in patients with systemic lupus erythematosus
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 20.12.2011
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|a Date Revised 18.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a Systemic lupus erythematosus (SLE) is an autoimmune disease accompanied by disturbed T-cell homeostasis. Dysbalance of T-helper-cell (Th) subsets (Th1/Th2/Th17) and regulatory T-cells (T(regs)) is suggested to contribute to the pathogenesis of SLE. Recent reports suggest functional deviation of T(regs) in terms of producing IL-17A, a process that may be aberrant in SLE. Therefore, we analyzed these T-cell subsets in SLE to test the hypothesis that aberrant T-cell subset skewing is present in SLE-patients. We investigated simultaneously the intracellular cytokines IFN-γ, IL-4 and IL-17A in CD4(+)T-cells as well as in T(regs). Skewing of T-cell subsets towards Th17 cells was observed in SLE-patients. Although the proportion of T(regs) was similar between SLE-patients and healthy controls, the ability of T(regs) to express IFN-γ and IL17A was impaired in SLE-patients. Even in quiescent SLE-patients T-cell homeostasis is aberrant in terms of skewing towards IL-17 producing T-cells
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| 650 |
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4 |
|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a FOXP3 protein, human
|2 NLM
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| 650 |
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7 |
|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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7 |
|a IL17A protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Interleukin-4
|2 NLM
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| 650 |
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|a 207137-56-2
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Bijl, Marc
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Huitema, Minke G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Limburg, Pieter C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kallenberg, Cees G M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Abdulahad, Wayel H
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 141(2011), 2 vom: 15. Nov., Seite 197-204
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:141
|g year:2011
|g number:2
|g day:15
|g month:11
|g pages:197-204
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2011.08.005
|3 Volltext
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|a AR
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|d 141
|j 2011
|e 2
|b 15
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|h 197-204
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