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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1021/la2028862
|2 doi
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|a eng
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| 100 |
1 |
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|a Adams, Nicholas M
|e verfasserin
|4 aut
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|a Design, synthesis, and characterization of nucleic-acid-functionalized gold surfaces for biomarker detection
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|c 2012
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 01.05.2012
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a Nucleic-acid-functionalized gold surfaces have been used extensively for the development of biological sensors. The development of an effective biomarker detection assay requires careful design, synthesis, and characterization of probe components. In this Feature Article, we describe fundamental probe development constraints and provide a critical appraisal of the current methodologies and applications in the field. We discuss critical issues and obstacles that impede the sensitivity and reliability of the sensors to underscore the challenges that must be met to advance the field of biomarker detection
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Biomarkers
|2 NLM
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| 650 |
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|a Nucleic Acids
|2 NLM
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| 650 |
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|a Gold
|2 NLM
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| 650 |
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|a 7440-57-5
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| 700 |
1 |
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|a Jackson, Stephen R
|e verfasserin
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|a Haselton, Frederick R
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1 |
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|a Wright, David W
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|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 28(2012), 2 vom: 17. Jan., Seite 1068-82
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|g pages:1068-82
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