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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la202198k
|2 doi
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|a pubmed24n0704.xml
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|a (NLM)21905710
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|a DE-627
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|c DE-627
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|a eng
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|a Faraji, Amir H
|e verfasserin
|4 aut
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|a Synthesis and characterization of a hydrogel with controllable electroosmosis
|b a potential brain tissue surrogate for electrokinetic transport
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 06.03.2012
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Electroosmosis is the bulk fluid flow initiated by application of an electric field to an electrolyte solution in contact with immobile objects with a nonzero ζ-potential such as the surface of a porous medium. Electroosmosis may be used to assist analytical separations. Several gel-based systems with varying electroosmotic mobilities have been made in this context. A method was recently developed to determine the ζ-potential of organotypic hippocampal slice cultures (OHSC) as a representative model for normal brain tissue. The ζ-potential of the tissue is significant. However, determining the role of the ζ-potential in solute transport in tissue in an electric field is difficult because the tissue's ζ-potential cannot be altered. We hypothesized that mass transport properties, namely the ζ-potential and tortuosity, could be modulated by controlling the composition of a set of hydrogels. Thus, poly(acrylamide-co-acrylic acid) gels were prepared with three compositions (by monomer weight percent): acrylamide/acrylic acid 100/0, 90/10, and 75/25. The ζ-potentials of these gels at pH 7.4 are distinctly different, and in fact vary approximately linearly with the weight percent of acrylic acid. We discovered that the 25% acrylic acid gel is a respectable model for brain tissue, as its ζ-potential is comparable to the OHSC. This series of gels permits the experimental determination of the importance of electrokinetic properties in a particular experiment or protocol. Additionally, tortuosities were measured electrokinetically and by evaluating diffusion coefficients. Hydrogels with well-defined ζ-potential and tortuosity may find utility in biomaterials and analytical separations, and as a surrogate model for OHSC and living biological tissues
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Acrylates
|2 NLM
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|a Hydrogels
|2 NLM
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|a acrylic acid
|2 NLM
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|a J94PBK7X8S
|2 NLM
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|a Cui, Jonathan J
|e verfasserin
|4 aut
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|a Guy, Yifat
|e verfasserin
|4 aut
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| 700 |
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|a Li, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gavigan, Colleen A
|e verfasserin
|4 aut
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| 700 |
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|a Strein, Timothy G
|e verfasserin
|4 aut
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| 700 |
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|a Weber, Stephen G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 22 vom: 15. Nov., Seite 13635-42
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:27
|g year:2011
|g number:22
|g day:15
|g month:11
|g pages:13635-42
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|u http://dx.doi.org/10.1021/la202198k
|3 Volltext
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