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231224s2012 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-011-0783-1
|2 doi
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|a pubmed24n0704.xml
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|a (DE-627)NLM211315893
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|a (NLM)21901442
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Zhang, Dawen
|e verfasserin
|4 aut
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| 245 |
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|a The role of cysteine conjugation in the detoxification of microcystin-LR in liver of bighead carp (Aristichthys nobilis)
|b a field and laboratory study
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|c 2012
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 24.04.2012
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a The role of glutathione (GSH) and cysteine (Cys) conjugates in the detoxification of microcystin-LR (MC-LR) in bighead carp (Aristichthys nobilis) was examined under laboratory and field conditions. Wild individuals of bighead carp were collected from 5 eutrophic lakes along the Yangtze River, while in laboratory experiment, bighead carp were injected intraperitoneally with 500 μg purified MC-LR/kg body weight (bw). Contents of MC-LR and its glutathione (MC-LR-GSH) and cysteine conjugates (MC-LR-Cys) in the liver of bighead carp were determined by liquid chromatography electrospray ionization mass spectrum (LC-ESI-MS). In laboratory experiment, low concentrations of MC-LR-GSH (mean: 0.042 μg/g dry weight (DW)) were always detectable, and the mean ratio of MC-LR-Cys to MC-LR-GSH was 6.55. While, in field study, relatively high MC-LR-Cys concentration (mean: 0.22 μg/g DW) was detected, whereas MC-LR-GSH was occasionally detectable, and the average ratio of MC-LR-Cys to MC-LR-GSH was as high as 71.49. A positive correlation was found between MC-LR-Cys concentration in the liver of bighead carp and MC-LR content in seston from the five lakes (r = 0.85). These results suggest that MC-LR-Cys might be much more important than MC-LR-GSH in the detoxification of MC-LR in fish liver, and that cysteine conjugation of MC-LR might be a physiological mechanism for the phytoplanktivorous bighead carp to counteract toxic cyanobacteria
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Marine Toxins
|2 NLM
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|a Microcystins
|2 NLM
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| 650 |
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|a cyanoginosin LR
|2 NLM
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|a EQ8332842Y
|2 NLM
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| 650 |
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|a Glutathione
|2 NLM
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|a GAN16C9B8O
|2 NLM
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| 650 |
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|a Cysteine
|2 NLM
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| 650 |
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|a K848JZ4886
|2 NLM
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| 700 |
1 |
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|a Yang, Qiang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Ping
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deng, Xuwei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dai, Ming
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 21(2012), 1 vom: 05. Jan., Seite 244-52
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:21
|g year:2012
|g number:1
|g day:05
|g month:01
|g pages:244-52
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|u http://dx.doi.org/10.1007/s10646-011-0783-1
|3 Volltext
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