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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.2796
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|a eng
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|a Xie, Xiulan
|e verfasserin
|4 aut
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|a Formyl migration product of chanoclavine-I aldehyde in the presence of the old yellow enzyme FgaOx3 from Aspergillus fumigatus
|b a NMR structure elucidation
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|c 2011
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|a Text
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|a ƒaComputermedien
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|a Date Completed 04.05.2012
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2011 John Wiley & Sons, Ltd.
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|a A previous study showed that together with the festuclavine synthase FgaFS, the old yellow enzyme FgaOx3 from Aspergillus fumigatus catalyzed the conversion of chanoclavine-I aldehyde to festuclavine in the biosynthesis of ergot alkaloids. In the absence of FgaFS, a mixture containing two compounds with a ratio of 7:3 was detected in the enzyme assay of FgaOx3. NMR experiments including (DQF)-COSY, HSQC, HMBC and NOESY identified their structures as E/Z isomers of N-methyl-N-[(5R,10R)-10-(2-oxo-propyl)-2,4,5,10-tetrahydrobenzo[cd]indol-5-yl]formamide and proved the migration of the formyl group at C-8 in chanoclavine I-aldehyde to N-6 in the identified products
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|a Letter
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|a Research Support, Non-U.S. Gov't
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|a Aldehydes
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|a Ergolines
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|a chanoclavine
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|a NADPH Dehydrogenase
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|a Wallwey, Christiane
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|a Matuschek, Marco
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|a Steinbach, Klaus
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|a Li, Shu-Ming
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 49(2011), 10 vom: 30. Okt., Seite 678-81
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