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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2011.07.004
|2 doi
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|a pubmed24n0704.xml
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|a (DE-627)NLM211208914
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|a (NLM)21889412
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a van Assen, Sander
|e verfasserin
|4 aut
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| 245 |
1 |
0 |
|a Cell-mediated immune responses to inactivated trivalent influenza-vaccination are decreased in patients with common variable immunodeficiency
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| 264 |
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1 |
|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 20.12.2011
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| 500 |
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|a Date Revised 24.10.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a Influenza-specific cell-mediated immune (CMI) responses can protect from influenza, but may be decreased in CVID-patients since defects in CMI responses have been demonstrated in CVID-patients. Therefore CMI responses were evaluated in 15 CVID-patients and 15 matched healthy controls (HC) by determining frequencies of interferon (IFN)γ-producing PBMC, and frequencies of IFNγ-, interleukin (IL)-2- and tumour necrosis factor (TNF)α-producing CD4+ and CD8+ T-cells before and after influenza vaccination using IFNγ enzyme-linked immunospot (IFNγ-ELISpot) and flow cytometry. Humoral responses were determined using haemagglutination inhibition assay. In CVID-patients the number of spotforming PBMC in the IFNγ-ELISpot did not increase following influenza vaccination, in contrast to HC. In flow cytometry, the frequencies of IFNγ-producing T-cells decreased in CVID-patients after influenza vaccination, while in HC the frequencies of IFNγ-production flow cytometry increased. Concluding, CMI responses following influenza vaccination are hampered in CVID-patients compared to HC. Additional protective strategies against influenza other than vaccination are warranted
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antibodies, Viral
|2 NLM
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| 650 |
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7 |
|a Influenza Vaccines
|2 NLM
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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7 |
|a Vaccines, Inactivated
|2 NLM
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| 650 |
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7 |
|a Vaccines, Subunit
|2 NLM
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| 650 |
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7 |
|a influvac
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a de Haan, Aalzen
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Holvast, Albert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Horst, Gerda
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gorter, Linda
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Westra, Johanna
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kallenberg, Cees G M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Telgt, Denise S C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Palache, Abraham M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Giezeman, Katinka M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bijl, Marc
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 141(2011), 2 vom: 15. Nov., Seite 161-8
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:141
|g year:2011
|g number:2
|g day:15
|g month:11
|g pages:161-8
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| 856 |
4 |
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|u http://dx.doi.org/10.1016/j.clim.2011.07.004
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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| 912 |
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|a GBV_NLM
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 141
|j 2011
|e 2
|b 15
|c 11
|h 161-8
|