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DE-627 |
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20250213045510.0 |
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231224s2011 xx ||||| 00| ||chi c |
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|a pubmed25n0704.xml
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|a (DE-627)NLM211101559
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|a (NLM)21878169
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Zhao, Hui-ying
|e verfasserin
|4 aut
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| 245 |
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|a The prognostic value of N-terminal pro-B-type natriuretic peptide in patients with severe sepsis and septic shock
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| 264 |
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 12.04.2012
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|a Date Revised 31.08.2011
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To evaluate the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with severe sepsis and septic shock
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|a METHODS: In a prospective study, clinical data of 50 patients with severe sepsis and septic shock were analyzed. Plasma NT-proBNP level was measured at 0, 24, 48 and 72 hours after admission to the intensive care unit (ICU) of a university hospital. Patients were divided into survival group and non-survival group according to 30-day mortality rate. The dynamic variation of plasma NT-proBNP level was observed and the difference of plasma NT-proBNP levels between two groups was compared. The predictive value of NT-proBNP on mortality was evaluated by receiver operating characteristic (ROC) curves. The potential confounding factors on NT-proBNP were assessed with linear regression analysis
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|a RESULTS: NT-proBNP levels (μg/L)at 0 hour after admission to ICU [20.86(14.28,23.92)] were significantly higher in non-survival group (n=20) compared with survival group [ n=30, 10.02 (5.58, 16.41), P<0.01], and the difference persisted to 72 hours [19.68 (13.90, 24.02) vs. 9.24 (4.30, 11.81), P<0.01], but there was no statistical difference of NT-proBNP levels among four time points. In the ROC curves for NT-proBNP at admission, the area under the curve(AUC) for hospital mortality was 0.842, and 95% confidence interval (CI) was 0.764-0.922, P<0.01. NT-proBNP greater than 13.30 μg/L at admission was an independent indicator of mortality (sensitivity 80.6%, specificity 70.2%). Linear regression analysis revealed that the oxygenation index (PaO(2)/FiO(2), r=-0.839, P=0.003), platelet count (PLT, r=-0.803, P=0.032), and sequential organ failure assessment (SOFA) scores at 0 hour after admission to ICU (r=0.874, P<0.001) had independent effects on NT-proBNP values at admission
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|a CONCLUSION: Plasma NT-proBNP level is a valuable prognostic factor for severe sepsis and septic shock patients
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|a English Abstract
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Peptide Fragments
|2 NLM
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| 650 |
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7 |
|a pro-brain natriuretic peptide (1-76)
|2 NLM
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| 650 |
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|a Natriuretic Peptide, Brain
|2 NLM
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| 650 |
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7 |
|a 114471-18-0
|2 NLM
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| 700 |
1 |
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|a Liu, Fang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Jie
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liu, Dan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a An, You-zhong
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
|d 1998
|g 23(2011), 8 vom: 30. Aug., Seite 467-70
|w (DE-627)NLM098227793
|x 1003-0603
|7 nnns
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| 773 |
1 |
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|g volume:23
|g year:2011
|g number:8
|g day:30
|g month:08
|g pages:467-70
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 23
|j 2011
|e 8
|b 30
|c 08
|h 467-70
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