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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1093/jxb/err251
|2 doi
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|a pubmed25n0703.xml
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|a (NLM)21865177
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
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|a Cornelius, Stefanie
|e verfasserin
|4 aut
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|a Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 28.03.2012
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|a Date Revised 17.03.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a PYD1 (dihydropyrimidine dehydogenase) initiates the degradation of pyrimidine nucleobases and is located in plastids. In this study, a physiological analysis of PYD1 employing T-DNA knockout mutants and overexpressors was carried out. PYD1 knockout mutants were restricted in degradation of exogenously provided uracil and accumulated high uracil levels in plant organs throughout development, especially in dry seeds. Moreover, PYD1 knockout mutants showed delayed germination which was accompanied by low invertase activity and decreased monosaccharide levels. Abscisic acid (ABA) is an important regulator of seed germination, and ABA-responsive genes were deregulated in PYD1 knockout mutants. Together with an observed increased PYD1 expression in wild-type seedlings upon ABA treatment, an interference of PYD1 with ABA signalling can be assumed. Constitutive PYD1 overexpression mutants showed increased growth and higher seed number compared with wild-type and knockout mutant plants. During senescence PYD1 expression increased to allow uracil catabolism. From this it is concluded that early in development and during seed production PYD1 is needed to balance pyrimidine catabolism versus salvage
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Pyrimidines
|2 NLM
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| 650 |
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|a Abscisic Acid
|2 NLM
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| 650 |
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|a 72S9A8J5GW
|2 NLM
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| 650 |
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|a Dihydrouracil Dehydrogenase (NADP)
|2 NLM
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| 650 |
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|a EC 1.3.1.2
|2 NLM
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| 650 |
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|a pyrimidine
|2 NLM
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| 650 |
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|a K8CXK5Q32L
|2 NLM
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| 700 |
1 |
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|a Witz, Sandra
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rolletschek, Hardy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Möhlmann, Torsten
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Journal of experimental botany
|d 1985
|g 62(2011), 15 vom: 28. Nov., Seite 5623-32
|w (DE-627)NLM098182706
|x 1460-2431
|7 nnas
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| 773 |
1 |
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|g volume:62
|g year:2011
|g number:15
|g day:28
|g month:11
|g pages:5623-32
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| 856 |
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|u http://dx.doi.org/10.1093/jxb/err251
|3 Volltext
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