Synthesis of poly-L-glutamic acid grafted silica nanoparticles and their assembly into macroporous structures

© 2011 American Chemical Society

Bibliographische Detailangaben
Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 27(2011), 19 vom: 04. Okt., Seite 12124-33
1. Verfasser: Kar, Mrityunjoy (VerfasserIn)
Weitere Verfasser: Pauline, Minois, Sharma, Kamendra, Kumaraswamy, Guruswamy, Gupta, Sayam Sen
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Polyglutamic Acid 25513-46-6 Silicon Dioxide 7631-86-9
Beschreibung
Zusammenfassung:© 2011 American Chemical Society
Polypeptide-coated silica nanoparticles represent an interesting class of organic-inorganic hybrids since the ordered secondary structure of the polypeptide grafts imparts functional properties to these nanoparticles. The synthesis of a poly-l-glutamic acid (PLGA) silica nanoparticle hybrid by employing N-carboxyanhydride (NCA) polymerization to synthesize the polypeptide chains and Cu catalyzed azide alkyne cycloaddition reaction to graft these chains onto the silica surface is reported. This methodology enables the synthesis of well-defined polypeptide chains that are attached onto the silica surface at high surface densities. The PLGA-silica conjugate particles are well dispersed in water, and have been thoroughly characterized using multinuclear ((13)C, (29)Si) solid state NMR, thermogravimetric analysis, Fourier transform infrared, dynamic light scattering, and transmission electron microscopy. The pH-dependent reversible aggregation of the PLGA-silica particles, driven by the change in PLGA structure, has also been studied. Preliminary results on the use of aqueous dispersions of silica-PLGA for the preparation of three-dimensional macroporous structures with oriented pores by ice templating methodology are also demonstrated. These macroporous materials, comprising a biocompatible polymer shell covalently attached to rigid inorganic cores, adopts an interesting lamellar structure with fishbone-type architecture
Beschreibung:Date Completed 26.01.2012
Date Revised 28.09.2011
published: Print-Electronic
Citation Status MEDLINE
ISSN:1520-5827
DOI:10.1021/la202036c