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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la202602q
|2 doi
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|a eng
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|a Fales, Andrew M
|e verfasserin
|4 aut
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|a Silica-coated gold nanostars for combined surface-enhanced Raman scattering (SERS) detection and singlet-oxygen generation
|b a potential nanoplatform for theranostics
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 26.01.2012
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|a Date Revised 09.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a This paper reports the synthesis and characterization of surface-enhanced Raman scattering (SERS) label-tagged gold nanostars, coated with a silica shell containing methylene blue photosensitizing drug for singlet-oxygen generation. To our knowledge, this is the first report of nanocomposites possessing a combined capability for SERS detection and singlet-oxygen generation for photodynamic therapy. The gold nanostars were tuned for maximal absorption in the near-infrared (NIR) spectral region and tagged with a NIR dye for surface-enhanced resonance Raman scattering (SERRS). Silica coating was used to encapsulate the photosensitizer methylene blue in a shell around the nanoparticles. Upon 785 nm excitation, SERS from the Raman dye is observed, while excitation at 633 nm shows fluorescence from methylene blue. Methylene-blue-encapsulated nanoparticles show a significant increase in singlet-oxygen generation as compared to nanoparticles synthesized without methylene blue. This increased singlet-oxygen generation shows a cytotoxic effect on BT549 breast cancer cells upon laser irradiation. The combination of SERS detection (diagnostic) and singlet-oxygen generation (therapeutic) into a single platform provides a potential theranostic agent
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Fluorescent Dyes
|2 NLM
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|a Singlet Oxygen
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|a 17778-80-2
|2 NLM
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|a Gold
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|a 7440-57-5
|2 NLM
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|a Silicon Dioxide
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|a 7631-86-9
|2 NLM
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|a Yuan, Hsiangkuo
|e verfasserin
|4 aut
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|a Vo-Dinh, Tuan
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 19 vom: 04. Okt., Seite 12186-12190
|w (DE-627)NLM098181009
|x 1520-5827
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|g volume:27
|g year:2011
|g number:19
|g day:04
|g month:10
|g pages:12186-12190
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|u http://dx.doi.org/10.1021/la202602q
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