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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la2016879
|2 doi
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|a pubmed24n0702.xml
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|a (DE-627)NLM210684569
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|a (NLM)21834565
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Leiske, Danielle L
|e verfasserin
|4 aut
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|a Insertion mechanism of a poly(ethylene oxide)-poly(butylene oxide) block copolymer into a DPPC monolayer
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 13.01.2012
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|a Date Revised 01.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a Interactions between amphiphilic block copolymers and lipids are of medical interest for applications such as drug delivery and the restoration of damaged cell membranes. A series of monodisperse poly(ethylene oxide)-poly(butylene oxide) (EOBO) block copolymers were obtained with two ratios of hydrophilic/hydrophobic block lengths. We have explored the surface activity of EOBO at a clean interface and under 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayers as a simple cell membrane model. At the same subphase concentration, EOBO achieved higher equilibrium surface pressures under DPPC compared to a bare interface, and the surface activity was improved with longer poly(butylene oxide) blocks. Further investigation of the DPPC/EOBO monolayers showed that combined films exhibited similar surface rheology compared to pure DPPC at the same surface pressures. DPPC/EOBO phase separation was observed in fluorescently doped monolayers, and within the liquid-expanded liquid-condensed coexistence region for DPPC, EOBO did not drastically alter the liquid-condensed domain shapes. Grazing incidence X-ray diffraction (GIXD) and X-ray reflectivity (XRR) quantitatively confirmed that the lattice spacings and tilt of DPPC in lipid-rich regions of the monolayer were nearly equivalent to those of a pure DPPC monolayer at the same surface pressures
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Epoxy Compounds
|2 NLM
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|a poly(ethylene oxide)-poly(butylene oxide) copolymer
|2 NLM
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|a 139323-06-1
|2 NLM
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|a 1,2-Dipalmitoylphosphatidylcholine
|2 NLM
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|a 2644-64-6
|2 NLM
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|a Polyethylene Glycols
|2 NLM
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|a 3WJQ0SDW1A
|2 NLM
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| 700 |
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|a Meckes, Brian
|e verfasserin
|4 aut
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| 700 |
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|a Miller, Chad E
|e verfasserin
|4 aut
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| 700 |
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|a Wu, Cynthia
|e verfasserin
|4 aut
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|a Walker, Travis W
|e verfasserin
|4 aut
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|a Lin, Binhua
|e verfasserin
|4 aut
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|a Meron, Mati
|e verfasserin
|4 aut
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|a Ketelson, Howard A
|e verfasserin
|4 aut
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|a Toney, Michael F
|e verfasserin
|4 aut
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|a Fuller, Gerald G
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 18 vom: 20. Sept., Seite 11444-50
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:27
|g year:2011
|g number:18
|g day:20
|g month:09
|g pages:11444-50
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|u http://dx.doi.org/10.1021/la2016879
|3 Volltext
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