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231224s2011 xx |||||o 00| ||eng c |
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7 |
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|a 10.1021/la202123e
|2 doi
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|a pubmed24n0701.xml
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|a (DE-627)NLM21040907X
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|a (NLM)21806013
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Clawson, Corbin
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Synthesis and characterization of lipid-polymer hybrid nanoparticles with pH-triggered poly(ethylene glycol) shedding
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| 264 |
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|c 2011
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 29.12.2011
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a Novel lipid-polymer hybrid nanoparticles are designed with a poly(ethylene glycol) (PEG) coating that is shed in response to a low pH trigger. This allows the nanoparticles to be stable during systemic circulation and at neutral pH, but destabilize and fuse with lipid membranes in acidic environments. The hybrid nanoparticles consist of a poly(lactic-co-glycolic acid) core with a lipid and lipid-PEG monolayer shell. To make the hybrid nanoparticles pH sensitive, a lipid-(succinate)-mPEG conjugate is synthesized to provide a hydrolyzable PEG stealth layer that is shed off the particle surface at low pH. The pH-sensitivity of the nanoparticles is tunable using the molar concentration of the lipid-(succinate)-mPEG incorporated in the lipid shell of the particles. Possible uses of these pH-sensitive nanoparticles include aggregating in acidic tumor microenvironments, escaping acidified endosomes, or aggregating in deep lung tissue for improved inhalation administration
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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|a Lipids
|2 NLM
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| 650 |
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a Succinic Acid
|2 NLM
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| 650 |
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7 |
|a AB6MNQ6J6L
|2 NLM
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| 700 |
1 |
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|a Ton, Linh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Aryal, Santosh
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Victoria
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Esener, Sadik
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Liangfang
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 27(2011), 17 vom: 06. Sept., Seite 10556-61
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:27
|g year:2011
|g number:17
|g day:06
|g month:09
|g pages:10556-61
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| 856 |
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|u http://dx.doi.org/10.1021/la202123e
|3 Volltext
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