Peri-operative characteristics of cerebral oxygen metabolism in patients with encephalopathy after orthotopic liver transplantation

OBJECTIVE: To investigate the feature of cerebral oxygen metabolism during peri-operative stage of orthotopic liver transplantation (OLT), in order to identify the difference between the patients with or without complicating encephalopathy after OLT, and the relationship between the cerebral oxygen...

Ausführliche Beschreibung

Bibliographische Detailangaben
Veröffentlicht in:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue. - 1998. - 23(2011), 7 vom: 13. Juli, Seite 396-400
1. Verfasser: Cai, Jun (VerfasserIn)
Weitere Verfasser: Sun, Hai-yun, Shen, Ning, Hei, Zi-qing
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue
Schlagworte:English Abstract Journal Article Research Support, Non-U.S. Gov't Blood Glucose Lactic Acid 33X04XA5AT Oxygen S88TT14065
LEADER 01000caa a22002652 4500
001 NLM210225645
003 DE-627
005 20250213014957.0
007 tu
008 231224s2011 xx ||||| 00| ||chi c
028 5 2 |a pubmed25n0701.xml 
035 |a (DE-627)NLM210225645 
035 |a (NLM)21787466 
040 |a DE-627  |b ger  |c DE-627  |e rakwb 
041 |a chi 
100 1 |a Cai, Jun  |e verfasserin  |4 aut 
245 1 0 |a Peri-operative characteristics of cerebral oxygen metabolism in patients with encephalopathy after orthotopic liver transplantation 
264 1 |c 2011 
336 |a Text  |b txt  |2 rdacontent 
337 |a ohne Hilfsmittel zu benutzen  |b n  |2 rdamedia 
338 |a Band  |b nc  |2 rdacarrier 
500 |a Date Completed 30.01.2012 
500 |a Date Revised 21.11.2013 
500 |a published: Print 
500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To investigate the feature of cerebral oxygen metabolism during peri-operative stage of orthotopic liver transplantation (OLT), in order to identify the difference between the patients with or without complicating encephalopathy after OLT, and the relationship between the cerebral oxygen metabolism and encephalopathy after OLT 
520 |a METHODS: Thirty patients undergoing OLT were studied. The patients were divided into two groups according to occurrence or not of encephalopathy after OLT: encephalopathy group and non-encephalopathy group. Blood samples were taken from radial artery and jugular vein simultaneously for blood gas analysis before operation, 25 minutes after onset of anhepatic phase, 30 minutes after graft reperfusion , 3 hours after graft reperfusion , and 24 hours after graft reperfusion. Cerebral arterial oxygen content (CaO(2)), oxygen content of jugular vein blood (CjvO(2)), cerebral arterial-venous oxygen content difference (Ca-jvO(2)), cerebral oxygen extraction ratio (CERO(2)) and cerebral blood flow/cerebral metabolic rate of oxygen ratio (CBF/CMRO(2)) were calculated, and the levels of blood glucose and lactic acid were recorded 
520 |a RESULTS: There were 11 patients (36.7%) complicated by encephalopathy after OLT. The quantity of red blood cell infusion, blood loss and the dosage of noradrenalin in encephalopathy group were significantly larger compared with non-encephalopathy group. The overall tendency of change in cerebral oxygen metabolism index was about the same for both groups, while CaO(2) and Ca-jvO(2) at 25 minutes after onset of anhepatic phase, 30 minutes after graft reperfusion and 3 hours after graft reperfusion , and CERO(2) at 30 minutes after graft reperfusion and 3 hours after graft reperfusion were significantly decreased compared with those before operation [CaO(2) (ml/L) in encephalopathy group: 132.4 ± 23.5 , 125.9 ± 17.6, 133.4 ± 11.1 vs. 148.5 ± 28.8, in non-encephalopathy group: 135.7 ± 22.4, 130.5 ± 20.0, 139.9 ± 21.2 vs. 148.9 ± 28.2; Ca-jvO(2) (ml/L) in encephalopathy group: 42.9 ± 13.2, 31.4 ± 12.3 , 32.3 ± 6.5 vs. 52.9 ± 23.5, in non-encephalopathy group: 33.0 ± 14.1, 26.6 ± 9.1, 30.6 ± 10.3 vs. 50.2 ± 23.2; CERO(2) in encephalopathy group: (24.9 ± 9.7)%, (24.4 ± 5.5)% vs. (35.4 ± 11.5)%, in non-encephalopathy group: (20.6 ± 7.3)%, (21.9 ± 7.0)% vs. (33.4 ± 13.1)%, all P < 0.05], and they returned to the levels before operation at 24 hours after graft reperfusion. Jugular venous oxygen saturation (SjvO(2)) and CBF/CMRO(2) ratio were significantly increased at 30 minutes after graft reperfusion and 3 hours after graft reperfusion compared with the levels before operation [SjvO(2) in encephalopathy group: 0.838 ± 0.105, 0.835 ± 0.065 vs. 0.709 ± 0.125, in non-encephalopathy group: 0.854 ± 0.074, 0.824 ± 0.074 vs. 0.713 ± 0.138; CBF/CMRO(2) ratio in encephalopathy group: 37.8 ± 16.6, 31.9 ± 6.8 vs. 20.9 ± 6.7 , in non-encephalopathy group: 37.8 ± 14.1, 35.7 ± 13.7 vs. 24.3 ± 14.0, all P <0.05], and they returned to the levels before operation at 24 hours after graft reperfusion. The overall tendency of change in blood glucose and lactic acid was about the same in both groups, while the levels of blood glucose increased significantly from anhepatic phase to 24 hours after graft reperfusion compared with the levels before operation , and the levels of lactic acid increased significantly from anhepatic phase to 3 hours after graft reperfusion compared with the levels before operation and returned to the levels before operation at 24 hours after graft reperfusion 
520 |a CONCLUSION: There are significant changes in the features of cerebral oxygen metabolism during OLT, but there is no difference between encephalopathy group and non-encephalopathy group. The occurrence of encephalopathy can be attributed to many factors, so the prevention and treatment should be comprehensive considered 
650 4 |a English Abstract 
650 4 |a Journal Article 
650 4 |a Research Support, Non-U.S. Gov't 
650 7 |a Blood Glucose  |2 NLM 
650 7 |a Lactic Acid  |2 NLM 
650 7 |a 33X04XA5AT  |2 NLM 
650 7 |a Oxygen  |2 NLM 
650 7 |a S88TT14065  |2 NLM 
700 1 |a Sun, Hai-yun  |e verfasserin  |4 aut 
700 1 |a Shen, Ning  |e verfasserin  |4 aut 
700 1 |a Hei, Zi-qing  |e verfasserin  |4 aut 
773 0 8 |i Enthalten in  |t Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue  |d 1998  |g 23(2011), 7 vom: 13. Juli, Seite 396-400  |w (DE-627)NLM098227793  |x 1003-0603  |7 nnns 
773 1 8 |g volume:23  |g year:2011  |g number:7  |g day:13  |g month:07  |g pages:396-400 
912 |a GBV_USEFLAG_A 
912 |a SYSFLAG_A 
912 |a GBV_NLM 
912 |a GBV_ILN_350 
951 |a AR 
952 |d 23  |j 2011  |e 7  |b 13  |c 07  |h 396-400