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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la201906f
|2 doi
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|a eng
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|a Wu, Libo
|e verfasserin
|4 aut
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|a Nanoparticle-stabilized colloids in compressible hydrofluoroalkanes
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 29.12.2011
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|a Date Revised 31.08.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a In this work, we show that nanoparticles (NPs) dispersed in compressible hydrofluoroalkanes (HFAs) at small volume fractions are capable of stabilizing micrometer-sized particle colloids, which otherwise flocculate due to strong van der Waals forces. Water-soluble, biodegradable NPs with a chitosan (CS) core, grafted with highly HFA-philic moieties, can be readily dispersed in the low dielectric HFAs and are capable of imparting stability to a wide range of therapeutic particles having different chemistries (polar or hydrophobic; small and large molecular weight, including peptides and proteins) and morphologies (micronized crystals or amorphous). These NP systems thus serve as a broadly applicable platform for the noninvasive delivery of therapeutics to and through the lungs using propellant-based, portable inhalers, and are also of potential relevance in other industries where HFAs are employed as solvents or propellants. This concept may also be applicable to other compressible solvents
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a Colloids
|2 NLM
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|a Hydrocarbons, Fluorinated
|2 NLM
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|a Chitosan
|2 NLM
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|a 9012-76-4
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|a da Rocha, Sandro R P
|e verfasserin
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 17 vom: 06. Sept., Seite 10501-6
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|x 1520-5827
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|g volume:27
|g year:2011
|g number:17
|g day:06
|g month:09
|g pages:10501-6
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|u http://dx.doi.org/10.1021/la201906f
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