A NMR reverse diffusion filter for the simplification of spectra of complex mixtures and the study of drug receptor interactions
Copyright © 2011 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 49(2011), 8 vom: 30. Aug., Seite 464-8 |
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| Weitere Verfasser: | , , |
| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2011
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article NMR screening STD T1ρ filter diffusion filter relaxation filter Complex Mixtures Cyclooxygenase Inhibitors Ligands Receptors, Drug mehr... |
| Zusammenfassung: | Copyright © 2011 John Wiley & Sons, Ltd. A reverse diffusion filter NMR experiment (Drev) is proposed for the study of small molecules in binding with macromolecules. The filtering efficiency of Drev to eliminate the signals of the macromolecule is shown to be superior to conventional transverse relaxation filters at least for macromolecules containing a significant fraction of flexible residues. The Drev filter was also a useful complement for ligand-based NMR screening in combination with saturation transfer difference experiments |
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| Beschreibung: | Date Completed 30.06.2015 Date Revised 03.11.2014 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.2786 |