Selective J-resolved-HMQC-1 and -2, new methods for measuring proton-proton coupling constants in strongly coupled spin systems
Copyright © 2011 John Wiley & Sons, Ltd.
| Veröffentlicht in: | Magnetic resonance in chemistry : MRC. - 1985. - 49(2011), 8 vom: 30. Aug., Seite 459-63 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
| Veröffentlicht: |
2011
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| Zugriff auf das übergeordnete Werk: | Magnetic resonance in chemistry : MRC |
| Schlagworte: | Journal Article 1H-1H coupling constants J-scaling selective J-resolved-HMQC selective excitation strongly coupled spin systems |
| Zusammenfassung: | Copyright © 2011 John Wiley & Sons, Ltd. Efficient pulse sequences for measuring (1)H-(1)H coupling constants (JHH) in strongly coupled spin systems, named selective J-resolved-HMQC-1 and -2, have been developed. In the strongly coupled spin systems such as -CH2-CHA(OH)-CHB(OH)-CH2-, measurements of (3)JHAHB are generally difficult owing to the complicated splitting caused by the adjacent CH2 protons. For easier and accurate measurements of (3)JHAHB in such a spin system, a selective excitation pulse is incorporated into the J-resolved HMQC pulse sequence. In the proposed methods, only two strongly coupled protons, HA and HB which are excited by a selective pulse, are observed as J-resolved HMQC signals. The cross peaks of HA and HB appear as doublets owing to (3)JHAHB along the F1 dimension in the selective J-resolved HMQC-1 and -2 experiments. The efficiency of the proposed pulse sequences has been demonstrated in application to the stereochemical studies of the complicated natural product, monazomycin |
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| Beschreibung: | Date Completed 21.05.2015 Date Revised 03.11.2014 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
| ISSN: | 1097-458X |
| DOI: | 10.1002/mrc.2778 |