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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1007/s10646-011-0706-1
|2 doi
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|a pubmed24n0697.xml
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|a (DE-627)NLM20901038X
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|a (NLM)21656160
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Châtel, A
|e verfasserin
|4 aut
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| 245 |
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|a MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 16.03.2012
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|a Date Revised 20.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a In the present study, we analyzed the effects of two major pollutants of the environment, tributyltin (TBT) and water-accommodated fraction (WAF) of diesel oil, on MAP kinase activation, apoptosis induction and DNA damage, in the marine sponge Suberites domuncula. Our results clearly demonstrated a differential activation of the MAPKs depending on the chemicals tested. TBT induced the activation of p38 and JNK while diesel oil enhanced activation of both ERK and p38. The activation of MAPKs was observed after 1 h exposure and 6 and 24 h of recovery in seawater. In addition, DNA fragmentation, assessed by two techniques, the Fast micromethod(®) and the TUNEL assay, was detected after sponges were treated with both chemicals. Moreover, the study of caspase 3/7 activity showed that apoptosis was induced and triggered with all concentrations of TBT but only at high diesel oil concentrations. After TBT exposure, a correlation was observed between JNK activation, caspase 3 activity and DNA damage while p38 activation followed the two latter parameters at high concentrations of diesel oil, suggesting that sponges enhanced a specific apoptotic pathway depending on the xenobiotic tested. This study demonstrated a high signal response by the sponge Suberites domuncula to the tested chemicals. Cell signaling pathway studies may thus be of use in water quality biomonitoring programs
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Biomarkers
|2 NLM
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|a Gasoline
|2 NLM
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|a Trialkyltin Compounds
|2 NLM
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| 650 |
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|a Water Pollutants, Chemical
|2 NLM
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| 650 |
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|a tributyltin
|2 NLM
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| 650 |
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|a 4XDX163P3D
|2 NLM
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| 650 |
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|a p38 Mitogen-Activated Protein Kinases
|2 NLM
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|a EC 2.7.11.24
|2 NLM
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| 650 |
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|a Caspase 3
|2 NLM
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|a EC 3.4.22.-
|2 NLM
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| 650 |
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|a Caspase 7
|2 NLM
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| 650 |
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|a EC 3.4.22.-
|2 NLM
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| 700 |
1 |
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|a Talarmin, H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hamer, B
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Schröder, H C
|e verfasserin
|4 aut
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| 700 |
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|a Müller, W E G
|e verfasserin
|4 aut
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| 700 |
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|a Dorange, G
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Ecotoxicology (London, England)
|d 1992
|g 20(2011), 8 vom: 01. Nov., Seite 1727-40
|w (DE-627)NLM098212214
|x 1573-3017
|7 nnns
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| 773 |
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|g volume:20
|g year:2011
|g number:8
|g day:01
|g month:11
|g pages:1727-40
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|u http://dx.doi.org/10.1007/s10646-011-0706-1
|3 Volltext
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