Interaction of cholesterol-conjugated ionizable amino lipids with biomembranes : lipid polymorphism, structure-activity relationship, and implications for siRNA delivery

Delivery of siRNA is a major obstacle to the advancement of RNAi as a novel therapeutic modality. Lipid nanoparticles (LNP) consisting of ionizable amino lipids are being developed as an important delivery platform for siRNAs, and significant efforts are being made to understand the structure-activi...

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Publié dans:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 27(2011), 15 vom: 02. Aug., Seite 9473-83
Auteur principal:	Zhang, Jingtao (Auteur)
Autres auteurs:	Fan, Haihong, Levorse, Dorothy A, Crocker, Louis S
Format:	Article en ligne
Langue:	English
Publié:	2011
Accès à la collection:	Langmuir : the ACS journal of surfaces and colloids
Sujets:	Journal Article Lipids RNA, Small Interfering Cholesterol 97C5T2UQ7J