Interaction of cholesterol-conjugated ionizable amino lipids with biomembranes : lipid polymorphism, structure-activity relationship, and implications for siRNA delivery

Delivery of siRNA is a major obstacle to the advancement of RNAi as a novel therapeutic modality. Lipid nanoparticles (LNP) consisting of ionizable amino lipids are being developed as an important delivery platform for siRNAs, and significant efforts are being made to understand the structure-activi...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 27(2011), 15 vom: 02. Aug., Seite 9473-83
1. Verfasser:	Zhang, Jingtao (VerfasserIn)
Weitere Verfasser:	Fan, Haihong, Levorse, Dorothy A, Crocker, Louis S
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2011
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Lipids RNA, Small Interfering Cholesterol 97C5T2UQ7J