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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la201086u
|2 doi
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|a pubmed24n0696.xml
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|a eng
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| 100 |
1 |
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|a Lin, Jia-Qi
|e verfasserin
|4 aut
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| 245 |
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|a A simulation study on nanoscale holes generated by gold nanoparticles on negative lipid bilayers
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 18.10.2011
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|a Date Revised 29.06.2011
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2011 American Chemical Society
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|a Understanding the interactions of gold nanoparticles (AuNPs) with cellular compartments, especially cell membranes, is of fundamental importance in obtaining their control in biomedical applications. An effort is made in this paper to investigate the interactions of 2.2 nm core AuNPs with negative model bilayer membranes by coarse-grained (CG) molecular dynamics (MD) simulation. The CG model of lipid bilayer was taken from Marrink et al. ( J. Phys. Chem. B 2004, 108, 750-760 ), whereas the CG AuNPs model was developed on the basis of both atomistic MD simulations and experimental data. It was found that AuNPs functionalized with cationic ligands penetrated into the negative bilayer membranes and generated significant disruptions on bilayers. The lipids surrounding the nanoparticle were highly disordered and the bulk surface of the bilayer exhibits some defective areas. Most importantly, it is observed that a nanoscale hole can be formed and expanded spontaneously on the peripheral regions of the 20 × 20 nm bilayer. The expansion of the hole is on the time scale of hundreds of nanosceonds. The fully expanded hole had a radius of ∼5.5 nm and could transport water molecules at a rate of up to ∼1100 molecule/ns. However holes could not be formed on a larger bilayer (28 × 28 nm). The factors that can eliminate hole formation on the bilayer also include the decrease of cationic lignads on the AuNP, the reduction of negative lipids in the bilayer, the release of bilayer surface tension, the lowering of temperature, and the addition of a high concentration of salt. The results suggest that a hole can only be formed on living cell membranes under extreme conditions
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Bilayers
|2 NLM
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|a Gold
|2 NLM
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|a 7440-57-5
|2 NLM
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| 700 |
1 |
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|a Zheng, Yong-Gang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Hong-Wu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Zhen
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 13 vom: 05. Juli, Seite 8323-32
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:27
|g year:2011
|g number:13
|g day:05
|g month:07
|g pages:8323-32
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|u http://dx.doi.org/10.1021/la201086u
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