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20250212185543.0 |
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231224s2011 xx ||||| 00| ||chi c |
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|a pubmed25n0694.xml
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|a (NLM)21575364
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Xu, Ying-Yong
|e verfasserin
|4 aut
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| 245 |
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|a Analysis of clinical outcomes of 63 children with acute monocytic leukemia
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1 |
|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 03.11.2011
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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| 520 |
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|a OBJECTIVE: To evaluate the outcomes of childhood acute monocytic leukemia (AML-M5) and explore the indications of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for children with AML-M5
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|a METHOD: Seventy-five AML-M5 patients and 201 non-AML-M5 AML patients were enrolled in this retrospective analysis. Event-free survival (EFS) and overall survival (OS) rates were estimated by Kaplan-Meier method and prognostic factors were evaluated by COX regression with SPSS
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|a RESULT: (1) Twelve patients gave up treatment after confirmed diagnosis. Two patients died on the second day after chemotherapy. Of the 61 patients, 73.8% (45/61) achieved complete remission (CR) after two courses of chemotherapy. The 5-year EFS rate was 34.5% ± 6.8%. But of the 117 non-AML-M5/M3 AML patients, the 5-year EFS rate was 51.0% ± 4.9%. (2) Multivariate analysis showed that age ≥ 10 y, the proportion of bone marrow blast cell counts ≥ 15% after the first induction therapy, not CR after two courses of chemotherapy were risk factors for the long-term prognosis. (3) Of the 20 patients whose bone marrow blast cell counts ≥ 15% after the first induction therapy, 5 patients who choose allo-HSCT had a better OS than the other 15 patients who choose chemotherapy only (60.0% ± 21.9% vs. 7.3% ± 7.1%, P = 0.024)
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|a CONCLUSION: Children with AML-M5 had a poorer prognosis than the other AML patients; patients whose bone marrow blast cell counts ≥ 15% after the first induction therapy chose allo-HSCT had a better prognosis. At present, there is no enough evidence to support that patients whose bone marrow blast cell counts < 15% after the first induction therapy should choose unrelated donor for allo-HSCT
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|a English Abstract
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|a Journal Article
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| 700 |
1 |
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|a Chen, Jing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xue, Hui-Liang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Tang, Jing-Yan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pan, Ci
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiang, Hua
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ye, Qi-Dong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Luo, Chang-Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Min
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Long-Jun
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 49(2011), 3 vom: 17. März, Seite 175-80
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
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|g volume:49
|g year:2011
|g number:3
|g day:17
|g month:03
|g pages:175-80
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|a AR
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|d 49
|j 2011
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|b 17
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|h 175-80
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