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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1021/la200522r
|2 doi
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|a pubmed24n0694.xml
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|a (DE-627)NLM208124683
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|a (NLM)21561105
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Guzmán, Eduardo
|e verfasserin
|4 aut
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| 245 |
1 |
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|a pH-induced changes in the fabrication of multilayers of poly(acrylic acid) and chitosan
|b fabrication, properties, and tests as a drug storage and delivery system
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 23.09.2011
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|a Date Revised 25.11.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Multilayers of poly(acrylic acid), PAA, and chitosan, CHI, have been built by the layer-by-layer (LbL) method from aqueous solutions at different pH values and analyzed by the dissipative quartz crystal microbalance (D-QCM) and ellipsometry. The results showed that under all of the assembly conditions considered the growth of the films is nonlinear. The thickness of the PAA layers increases as the pH of the assembling solutions decreases, whereas the adsorption of CHI is almost unaffected by the pH conditions. The comparison of the thickness obtained by D-QCM and by ellipsometry has allowed us to calculate the water content of the films, showing that the multilayers are highly hydrated, with an average water content higher than 20%. The analysis of D-QCM data has provided high-frequency values of the complex shear modulus that are in the megapascal range and shows a transition from mainly viscous to mainly elastic behavior for the added PAA layers, depending on the pH. The monomer surface density in each layer (obtained from the combination of ellipsometry and differential refractive index measurements) indicated that the monomer density depends on the assembly conditions. It was found that the adsorption kinetics is a bimodal process, with characteristic times that depend on the number and nature of the layers. Finally, the possibility of using of these multilayers as a drug storage and delivery system has been evaluated
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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7 |
|a Acrylic Resins
|2 NLM
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| 650 |
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7 |
|a Drug Carriers
|2 NLM
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| 650 |
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7 |
|a carbopol 940
|2 NLM
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| 650 |
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|a 4Q93RCW27E
|2 NLM
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| 650 |
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|a Chitosan
|2 NLM
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| 650 |
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|a 9012-76-4
|2 NLM
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| 650 |
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|a Propranolol
|2 NLM
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| 650 |
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7 |
|a 9Y8NXQ24VQ
|2 NLM
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| 700 |
1 |
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|a Cavallo, Jesica A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chuliá-Jordán, Raquel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gómez, César
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Strumia, Miriam C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ortega, Francisco
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rubio, Ramón G
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 11 vom: 07. Juni, Seite 6836-45
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:27
|g year:2011
|g number:11
|g day:07
|g month:06
|g pages:6836-45
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|u http://dx.doi.org/10.1021/la200522r
|3 Volltext
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