MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease

MASP2 haplotypes are associated with high risk of cardiomyopathy in chronic Chagas disease

Copyright © 2011 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 140(2011), 1 vom: 15. Juli, Seite 63-70
1. Verfasser: Boldt, Angelica B W (VerfasserIn)
Weitere Verfasser: Luz, Paola R, Messias-Reason, Iara J T
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't MASP2 protein, human EC 3.4.21.- Mannose-Binding Protein-Associated Serine Proteases
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520 |a Mannose-binding lectin (MBL) initiates complement on Trypanosoma cruzi through the MBL-associated serine protease 2 (MASP2). We haplotyped six MASP2 polymorphisms in 208 chronic chagasic patients, being 81 indeterminate and 123 symptomatic (76 with cardiac, 19 with digestive and 28 with cardiodigestive forms) and 300 healthy individuals from Southern Brazil, using PCR with sequence-specific primers. The g.1961795C, p.371D diplotype (short CD) occurred at a higher frequency among symptomatic patients, compared with the indeterminate group (P(Bf)=0.012, OR=3.11), as well as genotypes with CD, but not with the g.1945560A in the promoter in cardiac patients (P(Bf)=0.012, OR=13.54). CD haplotypes linked to the p.P126L and p.V377A variants were associated with reduced MASP-2 levels (P<0.0001) but not reduced MBL/MASP-2/C4 complexes. MASP2*CD genotypes, most of them generating low MASP-2 levels, are associated with high risk of chagasic cardiomyopathy. Rapid MASP2 genotyping might be used to predict the risk of symptomatic disease 
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700 1 |a Luz, Paola R  |e verfasserin  |4 aut 
700 1 |a Messias-Reason, Iara J T  |e verfasserin  |4 aut 
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