Radiation-sensitive diselenide block co-polymer micellar aggregates : toward the combination of radiotherapy and chemotherapy

We have developed a potential radiation-sensitive drug-delivery system using active diselenide-containing block co-polymer aggregates in aqueous solution that can load and release anticancer drugs. These aggregates were sensitive to even a low dose of γ-radiation, such as 5 Gy, which is close to the...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 27(2011), 10 vom: 17. Mai, Seite 5874-8
1. Verfasser: Ma, Ning (VerfasserIn)
Weitere Verfasser: Xu, Huaping, An, Liping, Li, Juan, Sun, Zhiwei, Zhang, Xi
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Antineoplastic Agents Drug Carriers Micelles Polymers Selenium Compounds Water 059QF0KO0R Polyethylene Glycols 3WJQ0SDW1A
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520 |a We have developed a potential radiation-sensitive drug-delivery system using active diselenide-containing block co-polymer aggregates in aqueous solution that can load and release anticancer drugs. These aggregates were sensitive to even a low dose of γ-radiation, such as 5 Gy, which is close to the radiation dose received by patients during a single radiotherapy treatment. This line of research may open an avenue for the combination of radiotherapy and chemotherapy 
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700 1 |a An, Liping  |e verfasserin  |4 aut 
700 1 |a Li, Juan  |e verfasserin  |4 aut 
700 1 |a Sun, Zhiwei  |e verfasserin  |4 aut 
700 1 |a Zhang, Xi  |e verfasserin  |4 aut 
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