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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2011.03.003
|2 doi
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|a pubmed24n0690.xml
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|a (NLM)21458378
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
1 |
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|a Tai, Ningwen
|e verfasserin
|4 aut
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| 245 |
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|a IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 08.08.2011
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|a Date Revised 09.04.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a This study was to determine whether BMDCs cultured in the presence of IL-10 (G/10-DCs) could promote T cell tolerance and prevent autoimmune diabetes in two different animal models of T1D. Our results showed that G/10-DCs suppressed both insulitis and spontaneous diabetes in NOD and HLA-DQ8/RIP-B7.1 mice. The suppression was likely to be mediated by T cells, as we found that regulatory CD4(+)CD25(+)Foxp3(+) cells were significantly increased in G/10-DC treated animals. In vivo, the G/10-DCs inhibited diabetogenic T cell proliferation; in vitro, they had reduced expression of costimulatory molecules and produced little IL-12/23 p40 or IL-6 but a large amount of IL-10 when compared with DCs matured in the presence of IL-4 (G/4-DC). We conclude that IL-10-treated DCs are tolerogenic and induce islet-directed immune tolerance, which was likely to be mediated by T regulatory cells. This non-antigen-specific DC-based approach offers potential for a new therapeutic intervention in T1D
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|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a B7-1 Antigen
|2 NLM
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| 650 |
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|a HLA-DQ Antigens
|2 NLM
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| 650 |
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|a HLA-DQ8 antigen
|2 NLM
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| 650 |
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|a IL10 protein, mouse
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 700 |
1 |
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|a Yasuda, Hisafumi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiang, Yufei
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhang, Li
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rodriguez-Pinto, Daniel
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yokono, Koichi
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sherwin, Robert
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wong, F Susan
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nagata, Masao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wen, Li
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 139(2011), 3 vom: 22. Juni, Seite 336-49
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:139
|g year:2011
|g number:3
|g day:22
|g month:06
|g pages:336-49
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2011.03.003
|3 Volltext
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