|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM20707478X |
| 003 |
DE-627 |
| 005 |
20231224001308.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2011 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2011.02.018
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0690.xml
|
| 035 |
|
|
|a (DE-627)NLM20707478X
|
| 035 |
|
|
|a (NLM)21450528
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liu, Li-Li
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Th17/Treg imbalance in adult patients with minimal change nephrotic syndrome
|
| 264 |
|
1 |
|c 2011
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 08.08.2011
|
| 500 |
|
|
|a Date Revised 17.11.2011
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2011 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a To determine whether Th17/Treg balance was abnormal in adult patients with minimal change nephrotic syndrome (MCNS), we studied 25 patients with new-onset MCNS and 20 normal persons. The results showed that MCNS patients exhibited a significant increase in Th17 number, Th17-related cytokines (IL-17 and IL-23), and transcription factor (RORγt) levels, as well as an obvious decrease in Treg number, Treg-related cytokines (TGF-β1 and IL-10), and transcription factor (Foxp3) levels. The Th17/Treg ratios increased along with increased proteinuria and decreased albumin levels in patients with MCNS. IL-17 protein expression was also detected in the renal biopsy tissue of MCNS patients, particularly in patients with acute renal failure. Further, Th17/Treg balance returned to normal after effective corticosteroids therapy in 16 MCNS patients. These results indicated that Th17/Treg imbalance existed in MCNS patients, suggesting a potential role of Th17/Treg imbalance in the pathogenesis of MCNS
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
7 |
|a FOXP3 protein, human
|2 NLM
|
| 650 |
|
7 |
|a Forkhead Transcription Factors
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-17
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-23
|2 NLM
|
| 650 |
|
7 |
|a Nuclear Receptor Subfamily 1, Group F, Member 3
|2 NLM
|
| 650 |
|
7 |
|a Transforming Growth Factor beta1
|2 NLM
|
| 650 |
|
7 |
|a Interleukin-10
|2 NLM
|
| 650 |
|
7 |
|a 130068-27-8
|2 NLM
|
| 650 |
|
7 |
|a RNA
|2 NLM
|
| 650 |
|
7 |
|a 63231-63-0
|2 NLM
|
| 700 |
1 |
|
|a Qin, Yan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Cai, Jian-Fang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wang, Hai-Yun
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Tao, Jian-Ling
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Hang
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Li-Meng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Ming-Xi
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Xue-Mei
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Li, Xue-Wang
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 139(2011), 3 vom: 15. Juni, Seite 314-20
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:139
|g year:2011
|g number:3
|g day:15
|g month:06
|g pages:314-20
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2011.02.018
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 139
|j 2011
|e 3
|b 15
|c 06
|h 314-20
|