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231224s2011 xx |||||o 00| ||eng c |
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|a 10.1111/j.1939-165X.2011.00305.x
|2 doi
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|a DE-627
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|e rakwb
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|a eng
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| 100 |
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|a Wess, Gerhard
|e verfasserin
|4 aut
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|a Utility of measuring plasma N-terminal pro-brain natriuretic peptide in detecting hypertrophic cardiomyopathy and differentiating grades of severity in cats
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 21.09.2011
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|a Date Revised 20.10.2016
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a ©2011 American Society for Veterinary Clinical Pathology.
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|a BACKGROUND: Cats with hypertrophic cardiomyopathy (HCM) often have no clinical signs or subtle signs. Measurement of N-terminal pro-brain natriuretic peptide (NT-proBNP) has been demonstrated in people to be highly specific for heart disease and also correlates with severity of HCM. NT-proBNP may also be valuable in detecting and grading HCM in cats, but results to date have been equivocal
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|a OBJECTIVES: The aims of this study were to evaluate NT-proBNP as a screening test for diagnosis of HCM in cats and determine an appropriate cut-off value and to determine if NT-proBNP concentrations correlated with severity of HCM in cats
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|a METHODS: Plasma NT-proBNP concentrations were measured in 201 cats using an ELISA designed for use in cats. Cats were classified using echocardiography as clinically healthy controls (n=99) or cats with equivocal (n=9), mild (n=15), moderate (n=17), or severe (n=61) HCM
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|a RESULTS: NT-proBNP concentrations (median; 25th-75th interquartile percentiles) in mildly (216.1; 87.6-392.5 pmol/L), moderately (282.7; 131.9-466.6 pmol/L), and severely (839.5; 655.3-1046.4 pmol/L) affected cats were significantly higher than those in healthy controls (18.9; 3.4-62.4 pmol/L). Concentrations in severely affected cats were significantly higher than in cats from other HCM groups. There was no significant difference between mild and moderate HCM. Cut-off values >49 pmol/L had a sensitivity of 97.8% and specificity of 66.7%; >100 pmol/L had a sensitivity of 92.4% and specificity of 93.9%; and >150 pmol/L had a sensitivity of 88% and a specificity of 100%
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|a CONCLUSIONS: NT-proBNP with a cut-off value of >100 pmol/L was useful in detecting even mild HCM. Cats with increased NT-proBNP concentrations should be examined by echocardiography
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|a Journal Article
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|a Peptide Fragments
|2 NLM
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|a pro-brain natriuretic peptide (1-76)
|2 NLM
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|a Natriuretic Peptide, Brain
|2 NLM
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| 650 |
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|a 114471-18-0
|2 NLM
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| 700 |
1 |
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|a Daisenberger, Patricia
|e verfasserin
|4 aut
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|a Mahling, Monia
|e verfasserin
|4 aut
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| 700 |
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|a Hirschberger, Johannes
|e verfasserin
|4 aut
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|a Hartmann, Katrin
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Veterinary clinical pathology
|d 1975
|g 40(2011), 2 vom: 08. Juni, Seite 237-44
|w (DE-627)NLM098159984
|x 1939-165X
|7 nnns
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| 773 |
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|g volume:40
|g year:2011
|g number:2
|g day:08
|g month:06
|g pages:237-44
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|u http://dx.doi.org/10.1111/j.1939-165X.2011.00305.x
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