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20250212115927.0 |
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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2011.01.007
|2 doi
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|a pubmed25n0687.xml
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|a (DE-627)NLM206096194
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|a (NLM)21345739
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Rubbo, Pierre-Alain
|e verfasserin
|4 aut
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| 245 |
1 |
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|a The potential impact of CD4+ T cell activation and enhanced Th1/Th2 cytokine ratio on HIV-1 secretion in the lungs of individuals with advanced AIDS and active pulmonary infection
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 23.06.2011
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|a Date Revised 21.11.2013
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2011 Elsevier Inc. All rights reserved.
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|a Bronchoalveolar lavage fluid (BALF) provides a source of mucosal CD4(+) T cells. We investigated the physiological properties of T lymphocytes from BALF and blood and their role on the dynamic of HIV-1 replication among AIDS patients with active lung infections. Pulmonary CD4(+) T cells consist mainly of effector memory cells (CD45RO(+) and CCR7(-)) with increased expression of activation markers (HLA-DR(+) and CD69(+)) when compared to the blood counterpart. We observed a high frequency of BALF cells capable of secreting HIV-1-Ags suggesting that the local lung environment may support favorable conditions for CD4(+) T lymphocytes harboring HIV-1 DNA to initiate the viral cycle. Nevertheless, the high number of IFN-γ-producing cells and the predominance of Th1 immune response in the lung could limit the secretion of HIV-1 RNA. In conclusion, the capacity of activated CD4(+) T cells to produce HIV-1 is driven by both the level and quality of cellular activation in the lung
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, CD
|2 NLM
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| 650 |
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|a CXCR4 protein, human
|2 NLM
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| 650 |
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|a Cytokines
|2 NLM
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| 650 |
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|a DNA, Viral
|2 NLM
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| 650 |
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|a HIV Antigens
|2 NLM
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| 650 |
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|a RNA, Viral
|2 NLM
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| 650 |
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|a Receptors, CCR5
|2 NLM
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| 650 |
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7 |
|a Receptors, CXCR4
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 650 |
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|a Cycloheximide
|2 NLM
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| 650 |
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|a 98600C0908
|2 NLM
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| 700 |
1 |
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|a Tuaillon, Edouard
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bolloré, Karine
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Foulongne, Vincent
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bourdin, Arnaud
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Nagot, Nicolas
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Van de Perre, Philippe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Desgranges, Claude
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Israël-Biet, Dominique
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Vendrell, Jean-Pierre
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 139(2011), 2 vom: 15. Mai, Seite 142-54
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
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| 773 |
1 |
8 |
|g volume:139
|g year:2011
|g number:2
|g day:15
|g month:05
|g pages:142-54
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2011.01.007
|3 Volltext
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|a GBV_USEFLAG_A
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 139
|j 2011
|e 2
|b 15
|c 05
|h 142-54
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