Dual role of anti-TNF therapy enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues

Dual role of anti-TNF therapy : enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues

Copyright © 2011 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 139(2011), 2 vom: 15. Mai, Seite 164-76
1. Verfasser: Bosè, Francesca (VerfasserIn)
Weitere Verfasser: Raeli, Lorenzo, Garutti, Cecilia, Frigerio, Elena, Cozzi, Alessandra, Crimi, Marco, Caprioli, Flavio, Scavelli, Rossana, Altomare, Gianfranco, Geginat, Jens, Abrignani, Sergio, Reali, Eva
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Clinical Trial Journal Article Research Support, Non-U.S. Gov't Anti-Inflammatory Agents, Non-Steroidal Antibodies, Monoclonal Antibodies, Monoclonal, Humanized Antigens, CD Bacterial Toxins Cytokines Enterotoxins mehr... Immunoglobulin G Receptors, Antigen, T-Cell Receptors, Tumor Necrosis Factor Superantigens Tumor Necrosis Factor-alpha Viral Matrix Proteins enterotoxin F, Staphylococcal Infliximab B72HH48FLU Adalimumab FYS6T7F842 Etanercept OP401G7OJC
Beschreibung
Zusammenfassung:Copyright © 2011 Elsevier Inc. All rights reserved.
The impact of anti-TNF therapy on systemic immune responses in patients has not been clearly defined. Here, we examined Th1/Th2/Th17 cytokine expression, activation and proliferation of peripheral T cells from patients with psoriasis and inflammatory bowel disease before and during anti-TNF therapy. In parallel, we calculated the correlation with the clinical response and we monitored cytokine expression in biopsies from inflamed tissues. We evidenced a dual role of TNF-blockade. In peripheral blood, it increased the expression of cytokines such as IL-17, IL-10, and IFN-γ, and enhanced the expression of activation markers and the proliferative response of CD4 T cells to TCR stimulation. By contrast, in biopsies from target tissues, TNF-blockade diminished the expression of Th17/Th1 cytokine and early inflammatory genes. Importantly, the enhanced T cell responses to TCR-stimulation did not impair the clinical response to the therapy and, in responder patients, occurred with the concomitant down-regulation of inflammatory genes in the target tissues
Beschreibung:Date Completed 23.06.2011
Date Revised 19.11.2015
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2011.01.015