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231223s2010 xx |||||o 00| ||eng c |
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|a 10.1155/2010/130429
|2 doi
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|a pubmed25n0686.xml
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Romay-Tallón, Raquel
|e verfasserin
|4 aut
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|a The coexpression of reelin and neuronal nitric oxide synthase in a subpopulation of dentate gyrus neurons is downregulated in heterozygous reeler mice
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|c 2010
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.01.2012
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|a Date Revised 03.12.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Reelin is an extracellular matrix protein expressed in several interneuron subtypes in the hippocampus and dentate gyrus. Neuronal nitric oxide synthase (nNOS) is also expressed by interneurons in these areas. We investigated whether reelin and nNOS are co-localized in the same population of hippocampal interneurons, and whether this colocalization is altered in the heterozygous reeler mouse. We found colocalization of nNOS in reelin-positive cells in the CA1 stratum radiatum and lacunosum moleculare, the CA3 stratum radiatum, and the dentate gyrus subgranular zone, molecular layer, and hilus. In heterozygous reeler mice, the colocalization of nNOS in reelin-positive cells was significantly decreased only in the subgranular zone and molecular layer. The coexpression of reelin and nNOS in several hippocampal regions suggests that reelin and nNOS may work synergistically to promote glutamatergic function, and the loss of this coexpression in heterozygous reeler mice may underlie some of the behavioral deficits observed in these animals
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|a Comparative Study
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Cell Adhesion Molecules, Neuronal
|2 NLM
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|a Extracellular Matrix Proteins
|2 NLM
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|a Nerve Tissue Proteins
|2 NLM
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|a Reelin Protein
|2 NLM
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|a Nitric Oxide
|2 NLM
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|a 31C4KY9ESH
|2 NLM
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|a Glutamic Acid
|2 NLM
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|a 3KX376GY7L
|2 NLM
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|a Nitric Oxide Synthase Type I
|2 NLM
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| 650 |
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|a EC 1.14.13.39
|2 NLM
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| 650 |
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|a Nos1 protein, mouse
|2 NLM
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| 650 |
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|a EC 1.14.13.39
|2 NLM
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| 650 |
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|a Reln protein, mouse
|2 NLM
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| 650 |
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|a EC 3.4.21.-
|2 NLM
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|a Serine Endopeptidases
|2 NLM
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|a EC 3.4.21.-
|2 NLM
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| 700 |
1 |
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|a Dopeso-Reyes, Iria G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lussier, April L
|e verfasserin
|4 aut
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| 700 |
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|a Kalynchuk, Lisa E
|e verfasserin
|4 aut
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| 700 |
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|a Caruncho, Hector J
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Neural plasticity
|d 1998
|g 2010(2010) vom: 06., Seite 130429
|w (DE-627)NLM098558390
|x 1687-5443
|7 nnas
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| 773 |
1 |
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|g volume:2010
|g year:2010
|g day:06
|g pages:130429
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| 856 |
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|u http://dx.doi.org/10.1155/2010/130429
|3 Volltext
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|d 2010
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|h 130429
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