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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.2725
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|a eng
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| 100 |
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|a Schraml, Jan
|e verfasserin
|4 aut
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|a Determination of substitution sites in monosubstituted five-membered aromatic heterocycles
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|c 2011
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 23.05.2011
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|a Date Revised 15.02.2011
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|a published: Print-Electronic
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|a Citation Status PubMed-not-MEDLINE
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|a Copyright © 2011 John Wiley & Sons, Ltd.
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|a Similar magnitudes of proton-proton couplings across three, four, and five bonds and proton-carbon couplings across two and three bonds combined with difficult to predict substituent effects make the results of an indiscriminate use of routine (COSY, HSQC, HMBC, etc.) techniques for substitution site determination in C-monosubstituted five-membered heteroaromatics suspect. As demonstrated on two examples of natural products, the use of 1,1-ADEQUATE leads to unambiguous substitution site determination lending thus further support to suggested inclusion of 1,1-ADEQUATE data into computer-assisted structure elucidation (CASE) protocols
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|a Letter
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|a Kubec, Roman
|e verfasserin
|4 aut
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1 |
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|a Kučerová, Petra
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 49(2011), 3 vom: 01. März, Seite 147-50
|w (DE-627)NLM098179667
|x 1097-458X
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|g volume:49
|g year:2011
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