Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients

Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients

Copyright © 2011 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 139(2011), 2 vom: 26. Mai, Seite 122-32
1. Verfasser: Siedlar, Maciej (VerfasserIn)
Weitere Verfasser: Strach, Magdalena, Bukowska-Strakova, Karolina, Lenart, Marzena, Szaflarska, Anna, Węglarczyk, Kazimierz, Rutkowska, Magdalena, Baj-Krzyworzeka, Monika, Pituch-Noworolska, Anna, Kowalczyk, Danuta, Grodzicki, Tomasz, Ziegler-Heitbrock, Loems, Zembala, Marek
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2011
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Clinical Trial Journal Article Research Support, Non-U.S. Gov't Antibodies, Monoclonal Antigens, CD FCGR3B protein, human Fc gamma receptor IIB GPI-Linked Proteins HLA-DR Antigens IL10 protein, human mehr... Immunoglobulins, Intravenous Lipopolysaccharide Receptors Lipopolysaccharides Receptors, IgG Tumor Necrosis Factor-alpha Interleukin-10 130068-27-8 Interleukin-12 187348-17-0
Beschreibung
Zusammenfassung:Copyright © 2011 Elsevier Inc. All rights reserved.
We have studied the effect of intravenous immunoglobulins (IVIG) on monocyte subpopulations and cytokine production in patients with CVID. The absolute number of CD14(+)CD16(++) monocytes decreased on average 2.5-fold 4h after IVIG and after 20h returned to the baseline. The cytokine level in the supernatants of peripheral blood mononuclear cells (PBMC) after ex vivo LPS stimulation demonstrated the >2-fold decrease in TNF production 4h after IVIG. The TNF expression, which is higher in the CD14(+)CD16(++) monocytes, was decreased in these cells by IVIG in 4/7 CVID cases. In vitro exposure of the healthy individuals' monocytes to the IVIG preparation resulted in reduced TNF production, which was overcome by blockade of the FcγRIIB in the CD14(+)CD16(++) CD32B(high) monocytes. Our data suggest that reduction in the number of CD14(+)CD16(++) monocytes and the blockade of their cytokine production via triggering CD32B can contribute to the anti-inflammatory action of IVIG
Beschreibung:Date Completed 23.06.2011
Date Revised 09.11.2022
published: Print-Electronic
CommentIn: Clin Immunol. 2011 May;139(2):105-6. doi: 10.1016/j.clim.2011.02.002. - PMID 21393066
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2011.01.002