|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM205610463 |
| 003 |
DE-627 |
| 005 |
20231223234258.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2011 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1021/la104736u
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0685.xml
|
| 035 |
|
|
|a (DE-627)NLM205610463
|
| 035 |
|
|
|a (NLM)21294552
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Fong, Celesta
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Monodisperse nonionic isoprenoid-type hexahydrofarnesyl ethylene oxide surfactants
|b high throughput lyotropic liquid crystalline phase determination
|
| 264 |
|
1 |
|c 2011
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 21.10.2014
|
| 500 |
|
|
|a Date Revised 02.12.2018
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a The neat and lyotropic phase behavior of eight new ethylene oxide amphiphiles (EO = 1-8) with a hexahydrofarnesyl chain (3,7,11-trimethyldodecyl) and narrow polydispersity (>98.5% purity) is reported. Below five EO units the behavior of the neat surfactants show only a glass transition, Tg ∼ -90 °C. Above four EO units, crystallization (Tcrys) and crystal-isotropic liquid (Tm) transitions are also observed that increase with degree of ethoxylation of the surfactant headgroup. The lyotropic liquid crystalline phase behavior spans a complex spectrum of surfactant-water interfacial curvatures. Specifically, inverse phases are present below ambient temperatures for EO < 4, with HFarn(EO)2 exhibiting an inverse hexagonal (H(II)) phase stable to dilution. The phase diagram of HFarn(EO)3 displays both the gyroid (Ia3d) and double diamond (Pn3m) inverse bicontinuous cubic phases, with the latter being thermodynamically stable in excess water within the physiological regime. There is a strong preference for planar bilayer structures at intermediate headgroup ethoxylation, with the crossover to normal phases occurring at HFarn(EO)(7-8) which exhibits normal hexagonal (H(I)) and cubic (Q(I)) phases at ambient temperatures. The toxicity of colloidal dispersions of these EO amphiphiles was assayed against normal breast epithelial (HMEpiC) and breast cancer (MCF7) cell lines. The IC50 of the EO amphiphiles was similar in both cell lines with moderate toxicity ranging from ca. <5 to 140 μM in an in vitro cell viability assay. Observations are qualitatively rationalized in terms of the molecular geometry of the surfactant. The physicochemical behavior of the HFarnesyl ethylene oxide amphiphiles is compared to other ethylene oxide surfactants
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Surface-Active Agents
|2 NLM
|
| 650 |
|
7 |
|a Terpenes
|2 NLM
|
| 650 |
|
7 |
|a Polyethylene Glycols
|2 NLM
|
| 650 |
|
7 |
|a 3WJQ0SDW1A
|2 NLM
|
| 650 |
|
7 |
|a Farnesol
|2 NLM
|
| 650 |
|
7 |
|a 4602-84-0
|2 NLM
|
| 650 |
|
7 |
|a Ethylene Oxide
|2 NLM
|
| 650 |
|
7 |
|a JJH7GNN18P
|2 NLM
|
| 700 |
1 |
|
|a Weerawardena, Asoka
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Sagnella, Sharon M
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Mulet, Xavier
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Krodkiewska, Irena
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chong, Josephine
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Drummond, Calum J
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 27(2011), 6 vom: 15. März, Seite 2317-26
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
|
| 773 |
1 |
8 |
|g volume:27
|g year:2011
|g number:6
|g day:15
|g month:03
|g pages:2317-26
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1021/la104736u
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_22
|
| 912 |
|
|
|a GBV_ILN_350
|
| 912 |
|
|
|a GBV_ILN_721
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 27
|j 2011
|e 6
|b 15
|c 03
|h 2317-26
|