|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM205252079 |
| 003 |
DE-627 |
| 005 |
20231223233601.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231223s2011 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2010.12.020
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0684.xml
|
| 035 |
|
|
|a (DE-627)NLM205252079
|
| 035 |
|
|
|a (NLM)21256088
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Doetschman, Thomas
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis
|
| 264 |
|
1 |
|c 2011
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 14.04.2011
|
| 500 |
|
|
|a Date Revised 20.10.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2010 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Calcineurin (CN) is a phosphatase that activates nuclear factor of activated T cells (NFAT). While the CN inhibitors cyclosporine A (CsA) and tacrolimus (FK506) can prevent graft rejection, they also cause inflammatory diseases. We investigated the role of calcineurin using mice deficient in the CN catalytic subunit Aβ (CNAβ). Cnab(-/-) mice exhibit defective thymocyte maturation, splenomegaly and hepatomegaly. Further, as Cnab(-/-) mice age, they exhibit spontaneous T-cell activation and enhanced production of proinflammatory cytokines (IL-4, IL-6, and IFNγ). FOXP3(+) T(reg) cells were significantly decreased in Cnab(-/-) mice likely contributing to increased T-cell activation. Interestingly, we found that CNAβ is critical for promotion of BCL-2 expression in FOXP3(+) T(reg) and for permitting TGFβ signaling, as TGFβ induces FOXP3 in control but not in Cnab(-/-) T-cells. Together, these data suggest that CNAβ is important for the production and maintenance of T(reg) cells and to ensure mature T-cell quiescence
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, N.I.H., Extramural
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
7 |
|a Cytokines
|2 NLM
|
| 650 |
|
7 |
|a Forkhead Transcription Factors
|2 NLM
|
| 650 |
|
7 |
|a Foxp3 protein, mouse
|2 NLM
|
| 650 |
|
7 |
|a Proto-Oncogene Proteins c-bcl-2
|2 NLM
|
| 650 |
|
7 |
|a Transforming Growth Factor beta
|2 NLM
|
| 650 |
|
7 |
|a Calcineurin
|2 NLM
|
| 650 |
|
7 |
|a EC 3.1.3.16
|2 NLM
|
| 650 |
|
7 |
|a protein phosphatase 3, catalytic subunit, beta isoform, mouse
|2 NLM
|
| 650 |
|
7 |
|a EC 3.1.3.16
|2 NLM
|
| 700 |
1 |
|
|a Sholl, Allyson
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Chen, Hwu dau rw
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Gard, Connie
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hildeman, David A
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Bommireddy, Ramireddy
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 3 vom: 28. März, Seite 321-30
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
|
| 773 |
1 |
8 |
|g volume:138
|g year:2011
|g number:3
|g day:28
|g month:03
|g pages:321-30
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2010.12.020
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 138
|j 2011
|e 3
|b 28
|c 03
|h 321-30
|