Ionization behavior of amino lipids for siRNA delivery : determination of ionization constants, SAR, and the impact of lipid pKa on cationic lipid-biomembrane interactions

Ionizable amino lipids are being pursued as an important class of materials for delivering small interfering RNA (siRNA) therapeutics, and research is being conducted to elucidate the structure-activity relationships (SAR) of these lipids. The pK(a) of cationic lipid headgroups is one of the critica...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 27(2011), 5 vom: 01. März, Seite 1907-14
1. Verfasser:	Zhang, Jingtao (VerfasserIn)
Weitere Verfasser:	Fan, Haihong, Levorse, Dorothy A, Crocker, Louis S
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2011
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Fluorescent Dyes Lipids Liposomes Micelles Naphthalenesulfonates RNA, Small Interfering Surface-Active Agents 2-(4-toluidino)-6-naphthalenesulfonic acid 7724-15-4