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NLM204894875 |
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DE-627 |
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20250212084858.0 |
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231223s2011 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2010.12.005
|2 doi
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|a pubmed25n0683.xml
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|a (DE-627)NLM204894875
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|a (NLM)21216674
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a van de Wetering, Diederik
|e verfasserin
|4 aut
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| 245 |
1 |
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|a IFN-α cannot substitute lack of IFN-γ responsiveness in cells of an IFN-γR1 deficient patient
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|c 2011
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| 336 |
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 14.04.2011
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| 500 |
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2010 Elsevier Inc. All rights reserved.
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|a Patients with complete IFN-γR deficiency are unable to respond to IFN-γ and have impaired Th1-immunity and recurrent, severe infections with weakly virulent Mycobacteria. Since IFN-α and IFN-γ share signalling pathways, treatment with IFN-α has been proposed in complete IFN-γR deficiency. We stimulated cells from healthy controls and from a patient lacking IFN-γR1 with IFN-α and IFN-γ, to establish whether IFN-α would substitute for IFN-γ effects. IFN-α induced STAT1 phosphorylation in monocytes of the IFN-γR1(-/-) patient, but did not prime for LPS-induced IL-12p70, IL-12p40, IL-23 or TNF production. In control cells, IFN-α inhibited the priming effect of IFN-γ on LPS-induced pro-inflammatory cytokine release. Finally, IFN-γ but not IFN-α induced killing of M. smegmatis in cultured macrophages. In conclusion, no evidence was found to support the use of IFN-α in IFN-γR-deficient patients as intervention against mycobacterial infection; on the contrary, treatment of individuals with IFN-α may even adversely affect host defence against Mycobacteria
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Interferon-alpha
|2 NLM
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| 650 |
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|a Interleukins
|2 NLM
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| 650 |
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|a Lipopolysaccharide Receptors
|2 NLM
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| 650 |
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|a Lipopolysaccharides
|2 NLM
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| 650 |
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|a Receptors, Interferon
|2 NLM
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| 650 |
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|a STAT1 Transcription Factor
|2 NLM
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| 650 |
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|a STAT1 protein, human
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a van Wengen, Annelies
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Savage, Nigel D L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van de Vosse, Esther
|e verfasserin
|4 aut
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| 700 |
1 |
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|a van Dissel, Jaap T
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 138(2011), 3 vom: 02. März, Seite 282-90
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:138
|g year:2011
|g number:3
|g day:02
|g month:03
|g pages:282-90
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2010.12.005
|3 Volltext
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| 952 |
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|d 138
|j 2011
|e 3
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|c 03
|h 282-90
|