OPN promotes survival of activated T cells by up-regulating CD44 in patients with oral lichen planus

Bibliographische Detailangaben
Veröffentlicht in:	Clinical immunology (Orlando, Fla.). - 1999. - 138(2011), 3 vom: 28. März, Seite 291-8
1. Verfasser:	Liu, Gui-Xiang (VerfasserIn)
Weitere Verfasser:	Sun, Jin-Tang, Yang, Mei-Xiang, Qi, Xiang-Min, Shao, Qian-Qian, Xie, Qi, Qu, Xun, Wei, Feng-Cai, Sun, Shan-Zhen
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2011
Zugriff auf das übergeordnete Werk:	Clinical immunology (Orlando, Fla.)
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't CD3 Complex CD44 protein, human Hyaluronan Receptors Granzymes EC 3.4.21.-

Beschreibung
Zusammenfassung:	Copyright © 2010 Elsevier Inc. All rights reserved. Oral lichen planus (OLP) is a chronic inflammatory disorder of oral mucosa, which represents cell-mediated autoimmune diseases. Pathological study demonstrated that abundant T lymphocytes infiltrated the oral mucosa, in which the activated T cells that trigger apoptosis of oral epithelial cells is an important mechanism for OLP. However, to date the molecular mechanisms underlying the T lymphocytes infiltration and accumulation in OLP remain unclear. In this paper, we found that the levels of plasma OPN were elevated and were associated with the up-regulated expressions of CD44 in OLP patients. In vitro, the addition of exogenous OPN can suppress the apoptosis of activated CD8(+) T cells via CD44, and this T cell resistance to apoptosis may be attributed to the reduction of endogenous mature granzyme B. Our results suggested that the abnormally elevated levels of OPN may contribute to the abnormal infiltration and accumulation of the activated T cells by up-regulating CD44 in OLP
Beschreibung:	Date Completed 14.04.2011 Date Revised 16.11.2017 published: Print-Electronic Citation Status MEDLINE
ISSN:	1521-7035
DOI:	10.1016/j.clim.2010.12.007