Clinical characteristics of 14 critically ill children with 2009 influenza A (H1N1)

OBJECTIVE: To summarize characteristics and outcomes of critically ill children with 2009 influenza A (H1N1)

Bibliographische Detailangaben
Veröffentlicht in:Zhonghua er ke za zhi = Chinese journal of pediatrics. - 1960. - 48(2010), 11 vom: 20. Nov., Seite 860-4
1. Verfasser: Bai, Zhen-jiang (VerfasserIn)
Weitere Verfasser: Ji, Wei, Xie, Min-hui, Li, Ying, Hua, Jun, Ren, Yan
Format: Aufsatz
Sprache:Chinese
Veröffentlicht: 2010
Zugriff auf das übergeordnete Werk:Zhonghua er ke za zhi = Chinese journal of pediatrics
Schlagworte:English Abstract Journal Article
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245 1 0 |a Clinical characteristics of 14 critically ill children with 2009 influenza A (H1N1) 
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500 |a Citation Status MEDLINE 
520 |a OBJECTIVE: To summarize characteristics and outcomes of critically ill children with 2009 influenza A (H1N1) 
520 |a METHOD: A prospective observational study of 14 critically ill children with 2009 influenza A (H1N1) in pediatric intensive care unit (PICU) in Suzhou between Oct. 1(st) 2009 and Dec. 25(th) 2009. The primary outcome measures included frequency and duration of mechanical ventilation and duration of ICU stay 
520 |a RESULT: Critical illness occurred in 14 patients with confirmed (n = 14), community-acquired 2009 influenza A virus (H1N1) infection. The mean (SD) age of the 14 patients with confirmed 2009 influenza A (H1N1) was (4.91 ± 4.14) years, 7 were female (50.0%). The median duration from symptom onset to hospital admission was (3.09 ± 1.30) days and from hospitalization to ICU admission was (0.95 ± 0.96) day. All the patients were severely hypoxemic [mean (SD) ratio of PaO2/FiO2 was (191.27 ± 80.58) mm Hg] at ICU admission. ARDS occurred in 11 cases (78.6%). Mechanical ventilation was applied for 10 patients (71.4%). The median duration of ventilation was (12.51 ± 10.03) days and ICU stay was (12.58 ± 10.65) days. The median length of time during which the real-time RT-PCR test results were positive was (17.27 ± 5.57) days; Comorbidities such as iron deficiency anemia, cerebral palsy and congenital heart disease were found in 8 cases (57.1%). The longer length of mechanical ventilation and ICU stay were found in cases with higher admission PRISM III Score and lower Pediatrics Critical Illness Score 
520 |a CONCLUSION: Critical illness due to 2009 influenza A (H1N1) in Suzhou occurred rapidly after hospital admission and was associated with severe hypoxemia, ARDS, a condition that required prolonged mechanical ventilation. There were myocardial damages in critically ill children with severe 2009 influenza A (H1N1) 
650 4 |a English Abstract 
650 4 |a Journal Article 
700 1 |a Ji, Wei  |e verfasserin  |4 aut 
700 1 |a Xie, Min-hui  |e verfasserin  |4 aut 
700 1 |a Li, Ying  |e verfasserin  |4 aut 
700 1 |a Hua, Jun  |e verfasserin  |4 aut 
700 1 |a Ren, Yan  |e verfasserin  |4 aut 
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